Headaches Flashcards
Treatment of headaches should begin with?
Non-pharmacological methods
Migraine treatment is classified as?
Specific/Nonspecific acute/abortive/symptomatic & preventive/prophylactic
Analgesics for migraine treatment are…
Nonspecific, Acute
Analgesics used for migraines?
aspirin, acetaminophen, naproxen, indomethacin, piroxicam, diclofenac, ibuprofen
Analgesic combination useful for moderate migraine?
Acetaminophen, Aspirin, Caffeine (Excedrin)
Barbiturates for migraine treatment are…
Nonspecific, Acute
Have barbiturates been shown effective in RCTs?
No
Barbiturates frequent side effects?
Drowsiness, dizziness, risk of overuse & withdrawal
Opioids for migraine treatment are…
Nonspecific, Acute
Opioids used for migraines?
Codein, meperidine, oxycodone, hydromorphone, morphine, methadone, butorphanol
Risks of opioid use?
High risk of overuse and development of chronic daily headaches – Should not be used more than 2 days/week
When are opioids for migraines most useful?
In pregnant patients (many other meds will be contraindicated)
Steroids for migraine treatment are…
Nonspecific, Acute
Steroids are most useful for?
Prolonged headache state (“status migrainosus”)
Ergotamines for migraine treatment are…
Specific, Acute
Ergotamine mxn?
Alpha-adrenergic & Serotonergic agonist
Ergotamine in combo with? Given as?
Caffeine; Oral tablet or suppository
Dihydroergotamine mxn?
Weak vasoconstrictor, 5HT1BD agonist: acts to reduce cell activity in the trigeminovascular system
DHE given as?
Nasal spray, IM, IV
DHE IV for?
status migrainosus
Common side effects of ergotamine and DHE?
Nausea (ergotamines more so than DHE), vomiting, chest pain, abdominal pain, dizziness
Ergotamine and DHE contraindicated in?
Pregnant women, uncontrolled HTN, sepsis, renal or hepatic failure, peripheral/coronary/cerebral vascular disease
Ergotamine and DHE use should not exceed…
2 dosage days/week
Premier migraine abortive meds?
Triptans
Triptans for migraine treatment are…
Speficic, acute
Name the seven available triptans.
Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan
Most widely used triptan?
Sumatriptan
Sumatriptan is most effective given as?
SC (versus oral or nasal)
Triptan mxn?
5HT1BD agonists: Penetrate the CNS and cause vasocnstriction of extracerebral intracranial vessels and inactivation of the trigeminal system.
Is there evidence of use of triptans during the aura phase?
No, but shown to be effective in reducing associated symptoms.
Triptan side effects?
Flushing, tingling, chest discomfort (noncardiac)
Triptans contraindicated in?
Vascular disease, uncontrolled HTN, complicated migraine syndromes
When is preventive therapy for migraine recommended?
More than 3 severe HAs/month, more than 2 mild-moderate HAs/week, inability to use effective symptomatic therapy, overuse of acute medications, patient preference and in special migraine syndromes
Avoid preventive meds for migraine when?
Pregnancy
Major medication groups used for preventive therapy for migraines?
Antidepressants, antihypertensives, antiepileptics, vitamins, minerals, many “off label”
Antidepressants for migraine treatment are…
Preventive
First antidepressants used for migraine treatment? Then?
TCAs, SSRIs
TCAs used for migraine treatment?
Amitryiptyline, nortriptyline, protriptyline
Only TCA with consisten support for migraine prevention?
Amitryptyline
SSRIs used for migraine treatment?
Fluoxetine, paroxetine, setraline (useful when coexistent depression)
TCA side effects?
Dry mouth, constipation, weight gain, cardiac toxicity, orthostatic hypotension
SSRI side effects?
weight gain, sexual dysfunction
Antihypertensives for migraine treatment are…
Preventive
Commonly used antihypertensive classes for preventive migraine therapy?
Betablockers & Calcium channel blockers
Beta-blockers used for preventive migraine tx? Which ones are FDA approved for this?
Timolol and propanolol (approved) + nadolol and atenolol (longer half life and tolerability, hence their use)
Antihypertensives side effects?
drwosiness, depression, hypotension, decreased libido, memory disturbance
Antihypertensives contraindicated in?
Asthma, diabetes, CHF, Raynaud’s
Most commonly used calcium channel blocker for preventive migraine tx? When is this most useful?
Verapamil – Considered most useful in those with prolonged/disabling aura & for complicated migrain syndromes
Side effects of verapamil?
Constipation, dizziness
Antiepileptics as migraine treatment are…
Preventive
What is divalproex sodium?
Extended release form of valproic acid formulation (AED)
AED approved for migraine prevention?
Divalproex sodium
Divalproex sodium side effects?
Sedation, hair loss, weight gain, tremor, changes in cognition, hepatotoxicity, blood dyscrasia, pancreatitis
Most frequently used AED for migraine prevention?
Topiramate (approved)
Topiramate side effects?
Changes in cognition, paresthesias, weight loss, kidney stones, acute angle-closure glaucoma, decreased sodium bicarbonate
Botox for migraine treatment is…
Preventive for chronic migraines (>15 days/month for >3 months)
Botox side effects?
injection site pain, HA post injection, neck weakness, ptosis
Most common acute drug therapy for TTH?
Simple analgesics
Analgesics in combo w/ what for acute TTH tx?
Caffeine, codeine, anxiolytics
Most effective NSAIDs for acute TTH tx?
naproxen, ketorolac, indomethacin
Will muscle relaxants help episodic TTH?
No
When should preventiv drug tx be considered for TTH?
If frequence >2/week, if duration is >4/hour, and if severity may lead to significant disability or med overuse. This is the mainstay therapy for chronic TTH.
Preferred preventive therapy for chronic TTH?
Antidepressants (TCAs, then SSRIs)
Which TCA is most effective in preventive CTTH tx?
Amitriptyline
Will muscle relaxants help prevent CTTH?
Yes. Example: Tizanidine
Can Botox be used in preventive CTTH tx?
Maybe
Therapies for cluster headache acute treatment? Which is considered first line?
Triptans (first line), oxygen, DHE, anasthetics (lidocaine)
Prophylactic therapy for cluster headaches can be?
Short-term, long-term
Short-term prophylactic therapy for cluster headaches?
Oral corticosteroids, ergotamine
Long-term prophylactic therapy for cluster headaches?
Verapamil, Topiramate, Divalproex, Sodium, Lithium
Lithium side effects?
Weakness, nausea, thirst, tremor, lethargy, blurred vision, slurred speech, vomiting, anorexia, diarrhea, confusion, nystagums, EPS, seizures
Avoid these with lithium? Why?
Indomethacin, Sodium-depleting diuretics – Increase lithium levels
Most common cause of chronic daily headaches?
Med overuse
Leading culprits of “rebound phenomenon”?
Caffeine & Barbiturates