CYP 450

Question 1

Most important CYP enzymes?

Answer 1

1A2, 2C9, 2C19, 2D6, 2E1, 3A4

Question 2

Substrates of 1A2?

Answer 2

Caffeine, Theophylline

Question 3

Substrates of 2C9?

Answer 3

Phenytoin, S-warfarin

Question 4

Substrates of 2C19?

Answer 4

Diazepem

Question 5

Substrates of 2D6?

Answer 5

Codeine

Question 6

Substrates of 2E1?

Answer 6

Paracetamol

Question 7

Substrates of 3A4?

Answer 7

Terfenadine, Verapamil

Question 8

Inducer of 1A2?

Answer 8

Smoking, Charred food

Question 9

Inducer of 2C9?

Answer 9

Rifampicin (Rifampin)

Question 10

Inducer of 2C19?

Answer 10

St. John’s Wort

Question 11

Inducer of 2D6?

Answer 11

Rifampicin (Rifampin)

Question 12

Inducer of 3A4?

Answer 12

St. John’s Wort

Question 13

Inhibitor of 1A2?

Answer 13

Grapefruit juice

Question 14

Inhibitor of 2C9?

Answer 14

Macrolides

Question 15

Inhibitor of 2C19?

Answer 15

Fluoxetine

Question 16

Inhibitor of 2D6?

Answer 16

Quinidine, Haloperidol

Question 17

Inhibitor of 3A4?

Answer 17

Ketoconazol, Itraconazole

Question 18

CYPs with polymorphisms?

Answer 18

2C9, 2C19, 2D6

Question 19

2C9 & 2C19 polymorphisms?

Answer 19

Poor metabolizers

Question 20

2D6 polymorphisms?

Answer 20

Poor & Extensive metabolizers

Question 21

Ethnic groups showing polymorphisms with 2C9/2C19?

Answer 21

African American, Asian, White (poly is poor)

Question 22

Ethnic groups showing polymorphisms with 2D6?

Answer 22

African American, Asian, White (poly is poor). Asian, Ethiopan, N. & S. Europeans (poly is ultra-extensive