CYP 450 Flashcards
Most important CYP enzymes?
1A2, 2C9, 2C19, 2D6, 2E1, 3A4
Substrates of 1A2?
Caffeine, Theophylline
Substrates of 2C9?
Phenytoin, S-warfarin
Substrates of 2C19?
Diazepem
Substrates of 2D6?
Codeine
Substrates of 2E1?
Paracetamol
Substrates of 3A4?
Terfenadine, Verapamil
Inducer of 1A2?
Smoking, Charred food
Inducer of 2C9?
Rifampicin (Rifampin)
Inducer of 2C19?
St. John’s Wort
Inducer of 2D6?
Rifampicin (Rifampin)
Inducer of 3A4?
St. John’s Wort
Inhibitor of 1A2?
Grapefruit juice
Inhibitor of 2C9?
Macrolides
Inhibitor of 2C19?
Fluoxetine
Inhibitor of 2D6?
Quinidine, Haloperidol
Inhibitor of 3A4?
Ketoconazol, Itraconazole
CYPs with polymorphisms?
2C9, 2C19, 2D6
2C9 & 2C19 polymorphisms?
Poor metabolizers
2D6 polymorphisms?
Poor & Extensive metabolizers
Ethnic groups showing polymorphisms with 2C9/2C19?
African American, Asian, White (poly is poor)
Ethnic groups showing polymorphisms with 2D6?
African American, Asian, White (poly is poor). Asian, Ethiopan, N. & S. Europeans (poly is ultra-extensive