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Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

MAOIs?

A

Tranylcypromine, Phenelzine

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2
Q

Tranylcypromine class?

A

MAOI

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3
Q

Phenelzine class?

A

MAOI

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4
Q

MAOI mxn?

A

Irr inhibit MAOa,b

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5
Q

MAOI for?

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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6
Q

MAOI side effects?

A

HTN crisis (w/ tyramine-rich foods), Seretonin syndrome (MAOI + SSRI), agitation (rare), delerium & seizures, anticholinergic, orthostatic HTN, sexual dysfunction, weight gain, sedation

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7
Q

Tricyclics?

A

Desipramine, Imipramine, Amitryptyline, Nortriptyline

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8
Q

Desipramine class?

A

Tricyclic

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9
Q

Imipramine class?

A

Tricyclic

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10
Q

Amitrytptiline class?

A

Tricyclic

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11
Q

Tricyclic mxn?

A

Block NE, 5HT reuptake (at varying potencies & selectivity); variably block muscarinic, alpha adren, DA, hist receptors

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12
Q

Tricyclics for?

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, (Amitrytpyline: prevention of tension headaches, migraines)

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13
Q

Tricyclic side effects?

A

Sympathomimetic (cardiac arrythmias and conduction defects, especially at OD), antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

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14
Q

What active metabolite does imipramine form? What about amitryptyline?

A

Desipramine; Nortriptyline.

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15
Q

Are the TCAs safe?

A

Not really…rarely used anymore.

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16
Q

Nortriptyline class?

A

Tricyclic

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17
Q

SSRIs?

A

Fluoxetine, Paroxetine, Sertraline, Escitalopram, Citalopram

18
Q

Fluoxetine class?

19
Q

Paroxetine class?

20
Q

Sertraline class?

21
Q

Escitalopram class?

22
Q

Citalopram class?

23
Q

SSRI mxn?

A

Inhibit reuptake of 5HT (& NE to a lesser extent)

24
Q

SSRI for?

A

depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

25
Q

Which SSRIs is a potent P450 inhibitor?

A

Fluoxetine & Paroxetine. Fluoxetine forms norfluoxetine as an active metabolite

26
Q

SNRIs?

A

Duloxetine, Venlafaxine

27
Q

Duloxetine class?

28
Q

Venlafaxine class?

29
Q

SNRI mxn?

A

Inhibit reuptake of NE & 5HT

30
Q

SNRI for?

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

31
Q

Atypical antidepressants?

A

Bupropion, Mirtazapine

32
Q

Bupropion mxn?

A

Atypical: Blocks DA & NE reuptake

33
Q

Bupropion for?

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, nicotine abstinence

34
Q

Bupropion side effect?

A

Lowers seizure threshold

35
Q

Mirtazapine mxn?

A

Atypical: 5HT2a antagonist; Inhibit 5HT reuptake

36
Q

Mirtazapine for?

A

Depression, anziety, PTSD, chronic pain, enuresis, bulimia, alcoholism

37
Q

Lithium mxn?

A

??? – Depletes secondary messengers IP3 and DAG (which are important in alpha adrenergic and muscarinic cholinergic transmission)

38
Q

Lithium for?

A

Anti-manic/mood-stabilizing (bipolar); Long term cluster headache prevention

39
Q

Lithium side effects?

A

If elevated levels; neurotoxicity, cardiac toxicity, renal dysfunction. Drowsiness, weight gain, tremor, polydisplia, polyuria, avoid indomethacin and Na-depleting diuretics…Nausea & vomiting are early signs of lithium OD

40
Q

Besides lithium, what is also helpful in treating bipolar?

A

Anti-epileptics: Carbamazepine, Valproate, MAOIs (during depressive phases), concurrent use of benzodiazepines (b/c Li onset is slow), antipsychotics (when severe)

41
Q

SSRI side effects?

A

Serotionin syndrome, nausea, sexual dysfunction – fewer than TCAs

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