Hallmarks of cancer

Question 1

Therapeutic targeting of sustained proliferative signalling

Answer 1

EGFR inhibitors

Question 2

Therapeutic targeting of evading growth suppressors

Answer 2

Cyclin-dependent kinase inhibitors

Question 3

Therapeutic targeting of avoiding immune destruction

Answer 3

anti-CTLA4 mAb

Question 4

Therapeutic targeting of enabling replicative immortality

Answer 4

Telomerase inhibitors

Question 5

Therapeutic targeting of tumour-promoting inflammation

Answer 5

Anti-inflammatory drugs

Question 6

Therapeutic targeting of activating invasion and metastases

Answer 6

Inhibition of HGF/c-Met

Question 7

Therapeutic targeting of angiogenesis

Answer 7

Inhibiting VEGF

Question 8

Therapeutic targeting of genome instability and mutation

Answer 8

PARP inhibitors

Question 9

KRAS causes which cancer

Answer 9

Lung adenocarcinoma, colorectal adenocarcinoma

Question 10

Genetic mutation pancreatic cancer

Answer 10

KRAS

Question 11

Genetic mutation melanoma

Answer 11

BRAF
Serine threonine oritein kinase involved in MAPk pathway, phosphorylating and activating MEK
MAPK pathway promotes cell growth and proliferation

Question 12

Small cell lung cancer pathophys

Answer 12

TP53 mutation

Question 13

Pathophys large intestine cancer

Answer 13

APC gene mutated which normally encodes tumour suppressor proteins

Question 14

Kidney cancer pathophys

Answer 14

VHL gene inhibits HIGF which promotes angiogenesis