Cancer immunology Flashcards
1
Q
Cancers with highest rates of mutation
A
Lung (smoking) and skin (sun)
2
Q
What is the innate immune response?
A
Mucous membranes and skin
3
Q
Adaptive immune response
A
Humoral (ABs specific to antigen are created) and T cell immunity (cellular)
4
Q
What are the different types of central tolerance?
A
Deletion, anergy and indifferent ignorance
5
Q
What are the different types of peripheral tolerance?
A
Anergy, regulatory cells and deletion
6
Q
Peripheral T cell tolerance
A
- Treg interacts with peptide-MHC presented by APC which can inhibit effector T cells that recognise same antigen as Treg and effector T cells that recognise different antigens to Treg
- Neo-antigens presented via MHC complex which can active and harness immune system
