Haemostasis and Thrombosis in Practice Flashcards
How do you differentiate between haemophilia A and haemophilia B?
Measure factor VIII and IX levels
Which factor is lacking in haemophilia A?
Factor VIII
Which factor is lacking in haemophilia B?
Factor IX
How is haemophilia A inherited?
X-linked
What is the treatment for severe haemophilia A?
Recombinant factor VIII
What is the treatment for severe haemophilia B?
What are the complications of plasma derived factor VIII treatment?
What are the complications of plasma derived factor VIII treatment?
Hep A
Why do DDAVP and tranexamic acid not work in severe haemophila?
A base factor VIII level of around 3-5 is required
What is the main complication of treatment of severe haemophilia A with factor VIII concentrates?
Development of inhibitory antibodies so treatmetn will not work
What is the best treatment regimen for severe haemophilia A?
Aim to turn severe haemophilia to moderate - give a small amount of factor VIII every day
Thrombocytopenia presentation
Short history of of easy bruising and small red spots on her ankles Petechiae Menorrhagia Epistaxis Buccal bleeding
Possible causes of thrombocytopenia
AML
Aplastic anaemia
ITP
Does vitamin K cause thrombocytopenia?
No
What is the likely platelet count in a thrombocytopenic patient with spontaneous bruising and petechiae formation?
Reduced
Whcih underlying illnesses are associated with ITP?
HIV infection
SLE
Glandular fever
