Haemostasis

Question 1

What does prostacyclin do?

Answer 1

Inhibits platelet activation and is also an effective vasodilator

Question 2

How are clots refined to site of injury?

Answer 2

Natural anticoagulants stop spread of clot

Question 3

How are resting platelets and coagulation factors activated?

Answer 3

Abnormal surface uncovers collagen which the platelets recognise and adhere to
Tissue factor released from site and triggers coagulation cascade

Question 4

What are some signallers which platelets have surface receptors for in order to prep them for function?

Answer 4

ADP
Epinephrine
Thrombin

Question 5

What do platelets do in haemostasis?

Answer 5

Adhere to injury sites
Activate
Aggregate
Provide phospholipid surface for coagulation

Question 6

How does aspirin work?

Answer 6

Inhibits cyclooxygenase pathway which interrupts platelet aggregation

Question 7

What is Von Willebrand factor?

Answer 7

Adhesive and multimeric glycoprotein

Binds to collagen surfaces, factor 8

Question 8

What is Von Willebrand disease?

Answer 8

Blood disorder in which the blood can’t clot