Anaemia in practice Flashcards
What is a diagnostic test for anaemia?
Anti-intrinsic factor antibodies
What tests would confirm a diagnosis of pernicious anaemia?
Serum B12 and folate levels
How would you treat pernicious anaemia?
IM vitamin B12
What kind of anaemia would you suspect in a young female who presents tired, distracted, SOB, irritable?
Iron deficiency anaemia
What is a diagnostic test for iron deficiency anaemia?
Ferritin
What is the morphological description of iron deficiency anaemia?
Hypochromic microcytic anaemia
What are some factors you should consider in iron deficiency anaemia?
Bleeding (menorrhagia)
Pregnancy
Diet (vegetarian)
GI symptoms
What is a likely cause of hypochromic microcytic anaemia with normal ferritin?
Thalassaemia trait
What kind of inheritance for haemoglobinopathies?
Autosomal recessive
What does hepcidin do in anaemia of chronic disease?
Blocks ferroportin
What tests would you order when spherocytes appear on a blood film?
Reticulocyte count Bilirubin LDH Serum haptoglobin DAGT (Coomb's)
What does a positive DAGT test show?
Autoimmune haemolysis
Is DAGT usually positive in hereditary spherocytosis?
No
What are the main parts of painful sickle cell crisis management?
Analgesia Oxygen Fluids Antibiotics for fever Thromboprophylaxis
What measure should be considered in the event of severe anaemia, stroke or chest crisis?
Blood transfusion
