Guillain Barre Syndrome Flashcards
Guillain Barre is triggered by…
An infection (gastroenteritis or URTI)
What 3 infections if Guillain Barre particularly associated with?
Campylobacter jejuni
CMV
EBV
Guillain Barre syndrome result in d______ of the ___
demyelination of the PNS
What cells are attacked in Guillain Barre Syndrome?
Schwann cells (myelinating cells of PNS)
What group of people are most at risk of Guillain Barre Syndrome?
15-30 y/o males and 50-70 y/o males
The pathophysiology of Guillain Barre Syndrome is that of m_____ m_____
molecular mimicry
The antigens of the pathogen is very similar to those on Schwann cells. Results in antibody production which attack the Schwann cells causing demyelination and acute polyneuropathy
What are symptoms of Guillain Barre Syndrome
Present post-infection with:
Ascending symmetrical muscle weakness/paralysis
Loss of deep tendon reflexes
Some have autonomic involvement
Some have respiratory failure
How is Guillain Barre Syndrome diagnosed?
Nerve conduction studies
Lumbar puncture at L3/4 shows raised protein and normal WBCs (inflammation, no infection)
How do you treat Guillain Barre Syndrome?
Iv Ig for 5 days and plasma exchange
Venous Thrombus Embolus prophylaxis
If a patient with Guillain Barre Syndrome has an FVC of less than 0.8, what should be considered?
Intubation and ITU
Where do symptoms of Guillain Barre Syndrome start?
In feet and progress upwards
Symptoms peak within 2-4 weeks.
In Guillain Barre Syndrome, there may be peripheral loss of s_____ or n_____ p___
sensation, neuropathic pain
True or false: Guillain Barre syndrome may progress to the cranial nerves and cause facial weakness
True
In Guillain Barre syndrome, autonomic dysfunction can lead to u_____ r_____ or heart arrhythmias
urinary retention
How long does recovery of Guillain Barre Syndrome take?
Months to years
Mortality rate is 5% due to respiratory or CV complications
