Guillain-Bare Syndrome Flashcards
what is guillain bare syndrome
acute, immune-mediated, inflammatory, demylinating disorder with potential for chronic implications - immune system attacks schwann cells in PNS
which variant of GBS is most common
acute demyelinating inflammatory polyneuropathy (AIDP)
what is GBS characterized by
rapidly progessive ascending motor weakness and diminished reflexes - sensory, autonomic & brainstem abnormalities may occur
incidence of GBS, who is at most risk and at what age?
peaks in young adults 5th-8th decade - increases with age >60yrs
males > females
what triggers GBS?
can be idiopathic but half of cases occur after microbial infection
also - autoimmune disease, allergic, HIV/herpes, vaccines, surgery, post-natal
what infections cause GBS
bacterial - campylobacteriosis (undercooked food like poultry)
viral - hx of URI or GI infection, zika, epstein-barr, COVID
what does the progression of GBS look like?
progression for 12-24 hours then a period of nadir for 2-4wks then recovery begins
how do you typically recover with GBS
proximal to distal
motor or sensory dominant disease? and what does it look like?
motor - rapidly progresses
symmetrical, distal to proximal
leg weakness then arm weakness
hyporeflexia or areflexia
do sensory impairments occur with GBS?
symptoms of paraesthesia and hyperesthesias onset way later than motor
which CN are involved?
CN VII (facial) - smile, frowning, whistling, drinking through straw
CN III, IV, VI - double vision
CN IX, X - dysphagia and laryngeal paralysis
what other symptoms are present with GBS?
a lot of pain - neuropathic and msk
autonomic dysfunction - tachy, arrhythmias, OH, wide flucutuations of BP
respiratory difficulties
how is GBS diagnoses
clinical exam
CSF exam - increased protein levels
nerve conduction tests - reduced amplitude, decreased conduction
MRI - swelling/thickening of spinal nerve roots
what are the required features for GBS by the NINDS?
- progressive, symmetrical weakness of legs and arms (sometimes just legs initially) - ranging from weakness to total paralysis of everything
- areflexia or decreased reflexes in weak limbs
what are the supportive features for GBS by the NINDS?
- progression of symptoms <4wks
- relative symmetry
- mild sensory impairments or signs
- CN involvement, bilateral
- recovery starting 2-4wk after progression halt
- autonomic dysfunction
- pain
- no fever
- elevated protein in CSF
- electrodiagnostic abnormalities consistent w GBS
what features make GBS doubtful?
- sensory > motor loss
- marked, persistent asymmetry of weakness
- bowel/bladder dysfunction
- severe pulmonary dysfunction with little or no limb weakness
- fever at onset
what is AIDP
acute inflammatory demyelinating polyradiculoneuropathy
- progressive, symmetrical muscle weakness, absent or depressed DTRs
- precedes illness