BG disorders pt 2 Flashcards
corticobasal degeneration
asymmetric parkinsonism symptoms + early cognitive deficits
focal cortical and substantia nigra neuronal loss
who is CBD mainly seen in
women
S&S of CBD
parkinsonism symptoms
cognitive impairments
apraxia
myoclonus
aphasia
dystonia
hyperkinetic movement disorder characterized by involuntary muscle contractions that cause slow, repetitive movements or abnormal postures
early onset on dystonia looks like
limb involvement
adult onset of dystonia looks like
neck and/or facial involvement
dystonia S&S
typically patterned, twisting
sporadic foot cramping and/or toe dragging or excessive inversion during swing phase of gait
severe hand cramping with writing
when do you see dystonic movements in early stages
only appearing during voluntary movements or stress - can have triggers
improves with rest
treatment for dystonia
botox
antocholinergic, GABA, dopaminergic
surgery
tardive dyskinesia
drug induced disorder characterized by involuntary and uncontrolled stiff jerky movements of face and body
risk factors for tardive dyskinesia
age >55
older women
amount of drug ingested
long term use of drug
alcohol or drug abuse
black/asian
symptoms of tardive dyskinesia
slow onset of symptoms
dyskinesias of face
abnormal postural tone
huntingtons disease
genetic, progressive
uncontrolled movements, cognitive dysfunction and behavioral changes due to hyperactivity of basal nuclei circuitry
early stages of HD affects what area of brain
loss of striatum neurons in the indirect NO-GO pathway, causing disinhibition of thalamus
later stages of HD affects what area of brain
loss of striatium neurons in direct GO pathway
loss of widespread cortical neurons
