GU Flashcards
BPH
MC benign tumor in men: hyperplastic process d/t inc cell number; originates from Transition Zone*
- incidence is age related
Sxs: hesitancy, dec force of stream, sensation of incomplete emptying, double voiding, straining
- early: OVS
- late: IVS
Dx: eval sxs using AUA I-PSS survey
- DRE (round w/medium sulcus); UA, BUN/SCr; PSA
- Other: post-void residual, US, TRUS, bx, renal U/S
Tx: AUA 0-7: watchful waiting AUA 8+: - alpha 1a AAG: tamsulosin - 5 alpha reductase inhibitor: finasteride, dutasteride [dec PSA levels, cause ED, dec libido]
Refractory or complications: TURP
Erectile dysfunction
MC cause: atherosclerosis (MetSyn)
Sx: libido vs. erection vs. ejaculation
Dx: U/S or angiography
Tx:
- sildenafil (Viagra)
- tadalafil (Cialis)
- vardenafil (Levitra)
Other: injection of prostaglandin, vacuum or inflatable penis prosthesis
Hydrocele
Collections of serous fluid in tunica vaginalis or persistent processes vaginalis
Sxs: fluctuant nontender, ovoid, mobile
Congenital (MC, 0-2yo) - a/w inguinal hernia, communicate w/abd cavity
Secondary (men >40) - infection, trauma, torsion, CA, post renal transplant, radiation
Dx: transillumination* [can see through it, not solid]
- consider U/S to r/o other more serious pathology
Tx: refer to urology
- congenital resolve spontaneously
Varicocele
Engorgement of testicular veins (pampiniform plexus)
Sxs: acute onset may be indicative of RCC
- usually left sided
- asx or “bag of worms” feeling
- dec in size when patient supine
- may affect semen quality/fertility
Dx: PE
Tx: refer to urology for surgery
Stress incontinence
MC: middle aged women (post-vaginal deliveries)
- d/t weakened pelvic floor muscles
Sxs: involuntary loss of uring during periods of increased intraabdominal pressure
- coughing, laughing, sneezing, exercise
Tx:
- pelvic floor muscle training w/PT (kegels)
- biofeedback
- suburethral sling (surgery) if conservative mgmt fails
- last option: duloxetine
Urge incontinence
Causes:
- neurogenic (stroke)
- obstruction
- inflammation (cystitis)
- DM
- iatrogenic
Sxs: involuntary loss of urine preceded by urgency [leakage prior to reaching bathroom]
- detrusor instability
Dx: GU exam, stress test, PVR
Tx:
- bladder retraining*
- prompted voiding, kegels, fluid mgmt
- 2nd line: antimuscarinics (oxybutynin)
- surgery
Mixed incontinence
Stress incontinence + symptomatic urgency
Tx depending on predominant sx
Overflow incontinence
Causes: BPH, prostate CA, stricture, uterine prolapse
- meds: CCBs, nasal decongestant, antihistamine, antipsychotics, morphine
Sxs: involuntary loss of urine a/w bladder distension
- bladder outlet obstruction OR inadequate bladder contraction
Dx: PVR, catheter, urodynamics, imaging
Tx: correct reversible causes; timed voiding
- selective alpha blockers (Tamsulosin)
Phimosis
Contracted foreskin cannot be retracted over glans
- commonly d/t chronic infection* from poor hygiene
- usually uncircumscribed males
Sxs: edema, erythema, foreskin tenderness; purulent d/c; inability to retract foreskin
Tx: abx; possible circumcision (refer to uro)
Paraphimosis
Retracted foreskin over glans cannot be placed in normal position
- may lead to impaired blood and lymphatic flow
- resulting in arterial occlusion and possible glans necrosis
Tx:
- manual reduction* may require incision of constricting ring under L.A.
- circumcision by Uro = definitive tx
Cystitis
Uropathogen colonizes periurethral mucosa and ascends through urethra and bladder
- MC: e. coli
RF: prior UTI, Fhx, sex, new partner w/in last year, use of spermicide
- common in women after sex; looks like Chlamydia
Uncomplicated: absence of structural or functional abnormalities
Complicated: underlying renal disease
Sxs: acute dysuria, inc frequency, suprapubic pain
- systemic toxicity absent
Dx: UA > 10 WBC [+LE, nitrates] and Ucx > 10^3 cfu/ml
- urine pregnancy
Tx:
- <20% E coli: TMP-SMX 160/800mg bid x 3d
- > 20% E coli: Nitrofurantoin 100mg bid x 5d OR Fosfomycin 3g x 1
Other:
- cipro/levo x 3d (careful for c. diff)
- phenazopyridine (pyridium) for pain control and hot sitz baths
Epididymitis & Orchitis General
Inflammation of epididymis, testes +/- infection
- acute < 6wk
- subacute 6wk-3mo
- chronic >3mo
Orchitis: epididymis inflammation spreads to adjacent testicle
- isolated orchitis a/w mumps or amiodarone use*
Bimodal distribution: 16-30yo; 50-70yo [MC 18-35]
RF: unprotected sex, MSM, INC # of partners, STDs, GU abn
Sxs:
- testicular pain, swelling, usually beginning posteriorly over epididymis
- lower UTI sxs possible
- +/- fever
- assess CVA tenderness
- suprapubic pain to r/o UTI
Epididymitis & Orchitis Dx/Tx
Testicular exam
Prehn Sign: relief of pain w/elevation of testes* = epididymitis
Inguinal exam for hernia or LAD
First-void “dirty” UA:
- +LE, >10 WBC/hpf = urethritis, favoring dx of epididymitis
UCx
Gram stain: gram-negative intracellular diplococci = gonococcal
Testicular color doppler U/S: thickening epididymis w/INC blood flow suggesting hyperemia
Tx:
- sexually active men <35 (or older men w/RF for STI): ceftriaxone 250mg x1 IM + doxy 100mg po bid x 10d
- > 35 or no RF for STI: levofloxacin 500mg Po x 10d
supportive: NSAIDs for pain, ice/elevation of testes while at rest
Acute Bacterial Prostatitis
Inflammation of prostate from infection: ascending infection from bladder into prostatic ducts result in immune response secondary to bacterial infection resulting in edema and hyperemia of prostate
- MC adult men
Pathogens:
- men 14-35: N. gonorrhea, C. trachomatis [tx: cef + doxy]
- Boys < 14, men > 35: E. coli [tx: FQ or TMP-SMX]
Sxs: abrupt onset fever, chills; IVS; perineal/sacral/suprapubic pain
PE: gentle DRE = enlarged, tender, warm, boggy prostate
- abdominal exam to detect distended bladder
- CVAT
Dx: blood work if admitted
- UCx - gonorrhea/chlamydia NAAT
Tx: abx, hydration, pain control, straight cath prn
Chronic bacterial prostatitis
Prostate infection >3mo + urine culture shows same bug
- 80% e. coli; 15% enterococcus
Sxs: not ill appearing, just discomfort
- presents w/recurrent or relapsing UTIs, urethritis, or epididymitis w/same bacteria
- IVS, testicular/perineal/low back pain
- afebrile, normal DRE
Dx: UA, Clx
Tx:
- FQ x 4-6wk, may treat up to 3-4mo
- refer to uro