Good pastures Syndrome Flashcards
1
Q
Good pastures syndrome
A
Autoimmune disease in which antibodies attack the basement membrane in alveoli (lung) and glomeruli (kidneys).
2
Q
What does this cause in the lungs?
A
Pulmonary alveolar haemorrhage
3
Q
What does this cause in the kidneys?
A
Kidney disease (glomerulonephritis)
4
Q
Causes:
A
- Environmental: smoking/infection/lungs
2. Genetic susceptibility.
5
Q
What are the antibodies reacting to?
A
Auto relative antibodies react to α3 chain of type IV collagen present in the basement membranes of alveoli & glomeruli.
6
Q
Treatment
A
Smoking cessation, corticosteroids, cyclophosphamide, plasmapheresis.
