Good pastures Syndrome Flashcards

1
Q

Good pastures syndrome

A

Autoimmune disease in which antibodies attack the basement membrane in alveoli (lung) and glomeruli (kidneys).

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2
Q

What does this cause in the lungs?

A

Pulmonary alveolar haemorrhage

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3
Q

What does this cause in the kidneys?

A

Kidney disease (glomerulonephritis)

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4
Q

Causes:

A
  1. Environmental: smoking/infection/lungs

2. Genetic susceptibility.

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5
Q

What are the antibodies reacting to?

A

Auto relative antibodies react to α3 chain of type IV collagen present in the basement membranes of alveoli & glomeruli.

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6
Q

Treatment

A

Smoking cessation, corticosteroids, cyclophosphamide, plasmapheresis.

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