GOat And OA Pharm

Question 1

What are two topical nsaids for OA

Answer 1

Diclofenac gel and sodium

use for knee only OA

Question 2

What is the only FDA approve topical nsaid for OA

Answer 2

Diclofenac gel 1%

Question 3

What is the MOA of topical salicylates

Answer 3

Local inhibition of COZ-2

Question 4

What is the ADE of ultra rapid Metz of Tramadol

Answer 4

Resp depression

Question 5

What is the MOA of glucosamine

Answer 5

Proposed Mechanism of Action: stimulates production of proteoglycans, which are the ground substance of articular cartilage, as well hyaluronic acid, which is responsible for the lubricating and shock absorbing properties of synovial fluid

Question 6

What is the MOA of chondrotin sulfate

Answer 6

Proposed Mechanism of Action:
Substance in cartilage that adds tensile strength
Composed of glucosamine and aminosugars
Increases intrarticular hyaluronic concentration and intrinsic viscosity
Promoted to decrease cartilage-destroying enzymes

Question 7

What is duloxetine approved for

Answer 7

To treat chronic MSK pain

Question 8

What are the perferred NSAIDs ofr RA

Answer 8

Ibuprofen, Meloxicam, Nabumetone, Naproxen

Question 9

What is the onset of DMARDS

Answer 9

Up to 3 months

Question 10

What is the MOA of methotrexate

Answer 10

Dihydrofolate Reductase Inhibitor:
Prevents synthesis of reduced folates that are necessary for purine synthesis
Interferes with DNA synthesis, repair, and cellular replication
Inhibits fast growing cells: cytokine production, epithelial cells in psoriasis
Leads to immunosuppressive and anti-inflammatory effects

Question 11

What is the reversal agent for methotrexate

Answer 11

Leucovorin

Question 12

What is the MOA of leflunomide

Answer 12

Prodrug, inhibits pyrimidine synthesis

Causes cell arrest of the autoimmune lymphocytes resulting in antiproliferative and anti-inflammatory effects

Question 13

What is the antidote ot leflunomide

Answer 13

Cholestyramine

Question 14

What is the MOA of hydroxychloroquine

Answer 14

Inhibits locomotion of neutrophils and chemotaxis of eosinophils
Impairs complement-dependent antigen-antibody reactions
Possible suppression of T-lymphocyte response to mitogens

Question 15

What is the MOA Of sulfasalazine

Answer 15

Prodrug that is cleaved by bacteria in the colon into sulfapyridine and 5-aminosalicylic acid (active)
Mechanism for RA is unclear; multiple pathways to decrease the production of IgA and IgM and suppress T-cell response

Question 16

What is the MOA of bio DMARDS

Answer 16

Mechanism of Action: block the pro-inflammatory cytokines TNFα, interleukin (IL), or bind on target receptors on T-cells to prevent the co-stimulation needed to fully activate T-cells

Question 17

What is the MOA of Colchicine

Answer 17

Mechanism of Action: binds to intracellular protein tubulin; prevents activation, degranulation, and migration of neutrophils associated with mediating some gout symptoms

Question 18

What is the MOA of allopurinol

Answer 18

Inhibits uric acid synthesis by inhibiting xanthine oxidase

Xanthine oxidase converts xanthine into uric acid

Question 19

What is the MOA of probenicid

Answer 19

Weak organic acids that promote renal clearance of uric acid by inhibiting proximal tubule urate-anion exchangers that mediate urate reabsorption