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Clinical Microbiology 1 > GNDC - Neisseria and Moraxella > Flashcards

GNDC - Neisseria and Moraxella Flashcards

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Biology 101 flashcards
1
Q

Most common N. meningitidis serogroups in US?

A

A, B, C, W-135

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2
Q

2 words. This technique is used to inoculate and streak selective media for optimum recovery of GC from a charcoal transport swab. Any growth on GC selective plates must be investigated.

A

Z STREAK

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3
Q

Military, air travel increase the risk of infection by this organism

A

N. meningitidis

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4
Q

This abbreviation refers to the disease seen when Neisseria gonorrhoeae invades the bloodstream causing dermatitis-arthritis syndrome

A

DGI (disseminated gonococcal infection)

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5
Q

Added to transport media, this detoxifying agent is particulalry suitable for the recovery of Neisseria gonorrhoeae.

A

CHARCOAL

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6
Q

A male urethral direct smear of Gram-negative diplococci intracellularly is ________ for gonorrhea with 95% specificity and sensitivity in young adult males.

A

DIAGNOSTIC

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7
Q

Ox: POS
Glucose: POS
Lactose, maltose, sucrose: NEG

A

N. gonorrhoeae

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8
Q

Stands for modified (reduced vancomycin) Thayer-Martin.

A

MTM

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9
Q

Antibiotic of choice for treating Moraxella infection

A

SxT

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10
Q

Preferred empiric treatment for N. gonorrhoeae

A

Single, high-dose ceftriaxone (IM) + azithromycin (oral)

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11
Q

The species name of this gndc in which the respiratory mucous membranes become inflamed, there s a thick build up of phlegm and and associated cough

A

CATARRHALIS

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12
Q

What would cause N. meningitidis to not be groupable?

A

Lack of capsule

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13
Q

Some strains of Neisseria gonorrhoeae are sensitive to this ABX therefore may not grow on selective media such as MML or MTM.

A

VANCOMYCIN

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14
Q

If Moraxella catarrhalis has this esterase, a blue-green colour will develop on the substrate disk.

A

BUTYRATE

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15
Q

Rifampin is given as ____ of close contacts in an outbreak of N. meningitidis invasive disease. If penicillin is used the organism can re-establish after treatment is stopped.

A

PROPHYLAXIS

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16
Q

Why is isolation of N. meningitidis from URT or LRT (throat swab) reported?

A

Carrier status

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17
Q

N. meningitidis infection characterized by fever, chills and possibly a petechial rash.

A

MENINGOCOCCEMIA

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18
Q

This CNS infection is characterized by fever, chills, possibly petechial rash, neck stiffness and cognitive disfuntction. Vomiting is common especially with children.

A

MENINGITIS

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19
Q

2 drugs of choice of N. meningitidis prophylaxis

A
  • Rifampin

- Azithromycin

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20
Q

If Neisseria meningitidis is isolated from a throat or sputum culture it usually does not suggest infection but rather a ____ and should be reported to indicate this possibility.

A

CARRIER

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21
Q

This media is used for Kirby-Bauer AST of N. meningitidis. The test is standardized for the addition of blood to a routine MH, and extended incubation (20-24 hrs) in CO2.

A

BAMH

22
Q

Primary reservoir of N. meningitidis

A

Nasopharyngeal carriers

23
Q

A neonate may present with this infection if an untreated mom with gonorrhea gives birth vaginally to her infant. For this reason, erythromycin drops are applied to neonates at birth (replacing silver nitrate).

A

CONJUNCTIVITIS

24
Q

hemmorhagic lesions seen in DIC

A

PURPURA

25
Q

Temperature for transporting N. gonorrhoeae

A

Room temperature

26
Q

Common specimens for M. catarrhalis

A
  • Sputum
  • Ear drainage
  • Eye swab
27
Q

Moraxella cataarhalis rapid ID?

A

BAP: NH, buff, opaque, friable/hockey puck

CHOC: gr-tan

s/ gndc

Oxidase, Butyrate: POS

28
Q

N. meningitidis on ML/CO2: G; N. gonorrhoeae on ML/CO2: G; M. catarrhalis on ML/CO2: __

A

NG

29
Q

Moraxella catarrhalis will be negative in the four common CHO-fermentation sugars (glu, mal, lac, suc) because it is ______.

A

ASACCHAROLYTIC

30
Q

The larger, flatter and gummier morphotypes of GC (notably on selective agar) are a result of a decrease in or lack of _____ .

A

PILIATION

31
Q

How to report if N. gonorrhoeae cefinase test POS? NEG?

A

POS: report penicillin: R
NEG: don’t report

32
Q

N. meningitidis emerging dominant serotype

A

B

33
Q

Nystatin, anisomycin or amphotericin B are added to media that selects for GC. These agents are inhibitory to ____.

A

FUNGUS

34
Q

Yet another abbreviation, this one refers to the disease seen when Neisseria gonorrhoeae ascends into the pelvis causing damage to the uterus, fallopian tubes and/ or ovaries.

A

PID

35
Q

Antibiotic of choice to “disinfect” meningococcal carriers b/c it reaches high concentration in saliva and tear

A

Minocycline

36
Q

This ABX is added to ML and TM to inhibit Gram-negatives.

A

COLISITIN

37
Q

Because 10-20% of females with gonorrhoeae are _____ they are untreated. This leads to PID.

A

ASYMPTOMATIC

38
Q

This abbreviation refers to the often fatal disease which can be seen with a variety of bacterial infections, including the meningococcus. Widespread clotting is followed by hemorrhage (depletion of clotting factors), gangrene (occlusion of blood vessels by clots), and severe hypotension and shock.

A

DIC

39
Q

The ABX of choice for treating N. meningitidis infections - however, broad spectrum cephalosporins (cefotaxime) are administered for meningitis.

A

PENICILLIN

40
Q

N. meningitidis agglutination test is performed with this reagent

A

Monoclonal antisera

41
Q

N. gonorrhoeae targets this type of epithelium

A

COLUMNAR

42
Q

This is a closed incubation system which if used with a TM will provide optimal conditions (moisture, media & CO2) for GC viability if delays in transport are inevitable.

A

JEMBEC

43
Q

Clinical significance of Moraxella catarrhalis

A
  • Pneumonia
  • Bronchitis
  • COPD
44
Q

This pathogenic Neisseria species is positive for fermentation of glucose and maltose.

A

MENINGITIDIS

45
Q

What further biochemical testing + results to perform for Moraxella ID if butyrate is NEG?

A

DNase: POS

Asaccharolytic

46
Q

For medico-legal reasons, ______________ tests (by another method = best practice) should be performed if an isolate is identified as Neisseria gonorrhoeae.

A

CONFIRMATORY

47
Q

Where to swab adult female for N. gonorrhoeae specimen

A

Endocervix

48
Q

Where to get N. gonorrhoeae swab if woman has had a hysterectomy

A

Urethra

49
Q

Name of transport tube for N. gonorrhoeae

A

Amies or Stuart’s transport with charcoal

50
Q

Temperature for charcoal transport tube

A

Room temeprature

51
Q

2 tests not used for N. gonorrhoeae detection anymore

A

CTA, CPPA

52
Q

Usual treatment for N. meningitidis infection

A

Penicillin

Clinical Microbiology 1 (12 decks)

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