GNDC - Neisseria and Moraxella

Question 1

Most common N. meningitidis serogroups in US?

Answer 1

A, B, C, W-135

Question 2

2 words. This technique is used to inoculate and streak selective media for optimum recovery of GC from a charcoal transport swab. Any growth on GC selective plates must be investigated.

Answer 2

Z STREAK

Question 3

Military, air travel increase the risk of infection by this organism

Answer 3

N. meningitidis

Question 4

This abbreviation refers to the disease seen when Neisseria gonorrhoeae invades the bloodstream causing dermatitis-arthritis syndrome

Answer 4

DGI (disseminated gonococcal infection)

Question 5

Added to transport media, this detoxifying agent is particulalry suitable for the recovery of Neisseria gonorrhoeae.

Answer 5

CHARCOAL

Question 6

A male urethral direct smear of Gram-negative diplococci intracellularly is ________ for gonorrhea with 95% specificity and sensitivity in young adult males.

Answer 6

DIAGNOSTIC

Question 7

Ox: POS
Glucose: POS
Lactose, maltose, sucrose: NEG

Answer 7

N. gonorrhoeae

Question 8

Stands for modified (reduced vancomycin) Thayer-Martin.

Answer 8

MTM

Question 9

Antibiotic of choice for treating Moraxella infection

Answer 9

SxT

Question 10

Preferred empiric treatment for N. gonorrhoeae

Answer 10

Single, high-dose ceftriaxone (IM) + azithromycin (oral)

Question 11

The species name of this gndc in which the respiratory mucous membranes become inflamed, there s a thick build up of phlegm and and associated cough

Answer 11

CATARRHALIS

Question 12

What would cause N. meningitidis to not be groupable?

Answer 12

Lack of capsule

Question 13

Some strains of Neisseria gonorrhoeae are sensitive to this ABX therefore may not grow on selective media such as MML or MTM.

Answer 13

VANCOMYCIN

Question 14

If Moraxella catarrhalis has this esterase, a blue-green colour will develop on the substrate disk.

Answer 14

BUTYRATE

Question 15

Rifampin is given as ____ of close contacts in an outbreak of N. meningitidis invasive disease. If penicillin is used the organism can re-establish after treatment is stopped.

Answer 15

PROPHYLAXIS

Question 16

Why is isolation of N. meningitidis from URT or LRT (throat swab) reported?

Answer 16

Carrier status

Question 17

N. meningitidis infection characterized by fever, chills and possibly a petechial rash.

Answer 17

MENINGOCOCCEMIA

Question 18

This CNS infection is characterized by fever, chills, possibly petechial rash, neck stiffness and cognitive disfuntction. Vomiting is common especially with children.

Answer 18

MENINGITIS

Question 19

2 drugs of choice of N. meningitidis prophylaxis

Answer 19

• Rifampin

- Azithromycin

Question 20

If Neisseria meningitidis is isolated from a throat or sputum culture it usually does not suggest infection but rather a ____ and should be reported to indicate this possibility.

Answer 20

CARRIER

Question 21

This media is used for Kirby-Bauer AST of N. meningitidis. The test is standardized for the addition of blood to a routine MH, and extended incubation (20-24 hrs) in CO2.

Answer 21

BAMH

Question 22

Primary reservoir of N. meningitidis

Answer 22

Nasopharyngeal carriers

Question 23

A neonate may present with this infection if an untreated mom with gonorrhea gives birth vaginally to her infant. For this reason, erythromycin drops are applied to neonates at birth (replacing silver nitrate).

Answer 23

CONJUNCTIVITIS

Question 24

hemmorhagic lesions seen in DIC

Answer 24

PURPURA

Question 25

Temperature for transporting N. gonorrhoeae

Answer 25

Room temperature

Question 26

Common specimens for M. catarrhalis

Answer 26

- Sputum - Ear drainage - Eye swab

Question 27

Moraxella cataarhalis rapid ID?

Answer 27

BAP: NH, buff, opaque, friable/hockey puck CHOC: gr-tan s/ gndc Oxidase, Butyrate: POS

Question 28

N. meningitidis on ML/CO2: G; N. gonorrhoeae on ML/CO2: G; M. catarrhalis on ML/CO2: __

Answer 28

NG

Question 29

Moraxella catarrhalis will be negative in the four common CHO-fermentation sugars (glu, mal, lac, suc) because it is ______.

Answer 29

ASACCHAROLYTIC

Question 30

The larger, flatter and gummier morphotypes of GC (notably on selective agar) are a result of a decrease in or lack of _____ .

Answer 30

PILIATION

Question 31

How to report if N. gonorrhoeae cefinase test POS? NEG?

Answer 31

POS: report penicillin: R NEG: don't report

Question 32

N. meningitidis emerging dominant serotype

Answer 32

B

Question 33

Nystatin, anisomycin or amphotericin B are added to media that selects for GC. These agents are inhibitory to ____.

Answer 33

FUNGUS

Question 34

Yet another abbreviation, this one refers to the disease seen when Neisseria gonorrhoeae ascends into the pelvis causing damage to the uterus, fallopian tubes and/ or ovaries.

Answer 34

PID

Question 35

Antibiotic of choice to "disinfect" meningococcal carriers b/c it reaches high concentration in saliva and tear

Answer 35

Minocycline

Question 36

This ABX is added to ML and TM to inhibit Gram-negatives.

Answer 36

COLISITIN

Question 37

Because 10-20% of females with gonorrhoeae are _____ they are untreated. This leads to PID.

Answer 37

ASYMPTOMATIC

Question 38

This abbreviation refers to the often fatal disease which can be seen with a variety of bacterial infections, including the meningococcus. Widespread clotting is followed by hemorrhage (depletion of clotting factors), gangrene (occlusion of blood vessels by clots), and severe hypotension and shock.

Answer 38

DIC

Question 39

The ABX of choice for treating N. meningitidis infections - however, broad spectrum cephalosporins (cefotaxime) are administered for meningitis.

Answer 39

PENICILLIN

Question 40

N. meningitidis agglutination test is performed with this reagent

Answer 40

Monoclonal antisera

Question 41

N. gonorrhoeae targets this type of epithelium

Answer 41

COLUMNAR

Question 42

This is a closed incubation system which if used with a TM will provide optimal conditions (moisture, media & CO2) for GC viability if delays in transport are inevitable.

Answer 42

JEMBEC

Question 43

Clinical significance of Moraxella catarrhalis

Answer 43

- Pneumonia - Bronchitis - COPD

Question 44

This pathogenic Neisseria species is positive for fermentation of glucose and maltose.

Answer 44

MENINGITIDIS

Question 45

What further biochemical testing + results to perform for Moraxella ID if butyrate is NEG?

Answer 45

DNase: POS | Asaccharolytic

Question 46

For medico-legal reasons, ______________ tests (by another method = best practice) should be performed if an isolate is identified as Neisseria gonorrhoeae.

Answer 46

CONFIRMATORY

Question 47

Where to swab adult female for N. gonorrhoeae specimen

Answer 47

Endocervix

Question 48

Where to get N. gonorrhoeae swab if woman has had a hysterectomy

Answer 48

Urethra

Question 49

Name of transport tube for N. gonorrhoeae

Answer 49

Amies or Stuart's transport with charcoal

Question 50

Temperature for charcoal transport tube

Answer 50

Room temeprature

Question 51

2 tests not used for N. gonorrhoeae detection anymore

Answer 51

CTA, CPPA

Question 52

Usual treatment for N. meningitidis infection

Answer 52

Penicillin