Glucose transporters

Question 1

Glucose

Answer 1

hydrophilic (not easily transported)

Question 2

Two types of transporters
1. GLUT
2. SGLT

Purpose: transport glucose into the cell

Answer 2

GLUTS
-14 different types
- sodium and ATP independent
-ubiquitous (existing or being everywhere at the same time)

SGLT
-sodium independent
-require ATP
-Located
a. intestine
b. renal tubules
c. blood brain barrier

Question 3

GLUT1

Answer 3

Blood
blood brain barrier
Heart (lesser extent)

Insulin independent

Question 4

GLUT2

Answer 4

Liver
Pancreas
small intestine

*only when glucose is very high

insulin independent
High Km
Low affinity for glucose

Question 5

GLUT3

Answer 5

1. Brain
2. Neurons
3. sperm

insulin independent
low Km
very high affinity for glucose.

Question 6

GLUT4

Answer 6

skeletal muscle
adipose tissue
heart

-Insulin dependent
-moderate Km
-Moderate affinity

Question 7

GLUT5

Answer 7

Enterocyte of intestinal epithelium (luminal side)

insulin independent
fructose transporter

Question 8

SGLT1

Answer 8

Enterocytes of intestinal epithelium (luminal side)

-insulin independent
ATP and Na dependent
-glucose absorption

Question 9

SGLT2 : glycosuria

Answer 9

1. proximal tubule of the. nephron (kidney)
   -so you dont lose glucose in the urine

A. insulin independent
B. ATP and Na+ dependent
C. Glucose retention