Acute phase proteins

Question 1

Acute Phase proteins

Answer 1

Acute-phase proteins (APPs) are a class of proteins whose concentrations in blood plasma either increase or decrease in response to inflammation

Question 2

Negative acute phase proteins

Answer 2

decrease during inflammation

-Include:
1. Albumin
2. Prealbumin
3. transferrin
4. retinol binding protein

Question 3

Positive acute phase protein

Answer 3

Increase during inflammation

include:
1. C Reactive protein
2. Ferritin

Question 4

Negative acute phase: Albumin

Answer 4

Half life: classification : 3 weeks.

Notable propeties:
1. Transporter
2. exerts colloidal osmotic pressure;
3. affected by trauma, surgery, stress and hydration status.

Hypoalbuminemia: Edema, inflammation

Hyperalbuminemia: Dehydration

Question 5

Negative Acute Phase: Prealbumin ( PAB; Transthyretin)

Answer 5

half life: 2-4 days

1. Quickly picks up updates in protein status.
2. During inflammation, liver prominently increase CRP production and decreases prealbumin production
3. decreased with ZINC deficiency
4. Transports THYROXINE
5. Works with RETINOL BINDING PROTEIN for Vit A transport

Question 6

Negative acute phase : Transferrin

Answer 6

half life: 8-10 days

1. TRANSFERs IRON to the bone marrow for production of hemoglobin (Hgb)
   -May be determined from total iron binding capacity (TIBC)
   -Directly affected by IRON status
   -Synthesis is increased when iron is low.
   -Transferrin levels reflect inflammation and are not useful as a measure of protein status.

Question 7

Negative acute phase: Retinol Binding Protein (RBP)

Answer 7

half life: about 2 hours

1. Transports Vitamin A

Question 8

Positive acute phase proteins : Ferritin

Answer 8

Men 12-300 ng/ml
Women 10-150 ng/ml

1. Stores iron
   FERRITIN increases during inflammation

Question 9

Positive Acute phase protein: C-Reactive Protein

Answer 9

Less than 10 ng/ml
-nonspecific marker of inflammation
-increased during inflammation
-Decreasing levels may signal when nutrition therapy may be helpful.
-Inverse relationship with Prealbumin (PAB) : As increased levels of CRP starts decreasing; PAB starts increasing.