Fundamental principles of Nutrition Flashcards
20 carbon omega 3 fatty acid with 5 double bonds (20:5) is:
EPA
Which Neurotransmitter is produced by the hypothalamus, is an appetite stimulate, and is a regulator of glucose.
Orexin (hypocretin) is a neuropeptide that regulates arousal, wakefulness, glucose, and appetite.
Methylation reactions occur in which detoxification phase?
phase II : Methylation is the primary method of removing toxins in the phase II liver detoxification system of the body.
Which of the following vitamins can be found with the enzyme, pyruvate carboxylase?
Biotin
Which nutrient is involved in the synthesis of carnitine?
Vitamin C ( carnitine, transports long chain fatty acids into the mitochondria for energy production)
which of the following hormones causes the gallbladder to contract and stimulates the pancreas to secrete enzymes?
CCK (stimulates secration of pancreatic enzymes, causes contraction of the GB, slows gastric emptying, increases motility in the colon.
A metabolic response to injury typically includes.
- negative nitrogen balance
- increased lipolysis
- increased glycogenolysis
- increased gluconeogenesis
NAD is a coenzyme derived from
Vitamin B3 (Nicotinamide adenine dinucleotide is a cofactor found in all living cells. )
Healthier sperm counts are most closely associated with:
optimal dietary zinc, folic acid, and antioxidants
-healthy zinc status is an important part of preconception care for men.
statistical power ?
The ability to detect a statistically significant result and depends on how many people were in the study and if the effect was large enough to actually help make a change
Your breastfeeding client is worried about her milk supply. What galactagogue could you recommend
fenugreek
Which of the following is the primary purpose of edema during pregnancy?
increase blood flow and nutrient transfer to the placenta and fetus
Food additives that are considered neurotoxins or excitotoxins include all of the following except?
Neurotoxins: Carageenan, smoke flavoring, yeast extract
Cochineal extract is a natural food dye made from an insect and is considered safe to consume with no known neurotoxic effects.
Which of the following promotes enterocyte proliferation?
L-glutamine (conditionally essential amino acid) dietary sources or suppleentation may be beneficial at times such as when an injury or illness is present.
Primary action of neurotensin is to:
Inhibit release of gastric emptying and acid secretion. It is a neurotransmitter. Regulates LH and prolactin release.
Baby is two weeks old. How do they tell mother they are hungry.
Infant brings hands to mouth, sucks on them, and moves head side to side (rooting reflex).
Crying is a late sign of hunger.
What does aldosterone do?
increases reabsorption of sodium in the kidneys
-Aldosterone keeps the sodium and potassium in your blood balanced by increasing reabsorption of sodium in the kidneys, which helps control your blood pressure and the balance of fluids in your body.
Which of the following U.S. food assistance programs supports primary, secondary and tertiary prevention?
WIC
-supplemental foods to improve the health status of participants (tertiary), nutrition education (primary), access to nutritious foods and other health related resources (secondary)
SNAP, HEAD START AND NATIONAL SCHOOL BREAKFAST support primary and secondary prevention.
Of the following, this nutrient is lost the greatest quantaties through sweating: Magnesium, zinc, iron, calcium
calcium
Sodium and chloride are lost in the largest quantities via sweat. Lesser amounts of calcium are also lost via sweat.
Study looking at relationship between CVD and smoking, type of tobacco, amount smoked, secondhand smoke.
Case control: begin with outcome and researchers do not have to follow people over time (retrospective)
Infant born preterm are at risk for death, neurological problems, congenital malformations and chronic health problems later in life. At what week is it considered preterm
Less than 37 weeks. Premature birth is when baby is before 37 weeks.
A serving size of wine
5 oz.
A group of individuals followed for 10 years. Every 2 years, come to facility to complete a survey.
Cohort (one or more samples are followed prospectively to investigate the causes of disease and to establish links between risk factors and health outcomes.
Major site of oxygen utilization in the cell is :
Mitochondria ( main site of energy transformation are the mitochondria, which provide over 90% of cellular ATP.
Creatine is synthesized from the amino acids:
Glycine, arginine, and methionine
Creatine, which forms creatinine, is synthesized from glycine and arginine with the addition of methyl group from the folate and cobalamin dependent methionine-SAM-homocysteine cycle.
Which of the following research designs describes and interprets an individual case?
case report: report of symptoms, diagnosis, and treatment of an individual patient.
A metabolic response to injury typically includes:
- free fatty acids used as energy
- Insulin resistance
- Glycerol converted to glucose in the liver
All of the following are released in response to injury:
- Interleukin
- Cytokines
- tumor necrosis factor
Daily intake requirements increase during pregnancy for all of the following nutrients
Zinc, Iodine, Chromium
Calcium DOES NOT increase
Wound healing, exercise, rapid weight loss, fevers, and burns are all factors that could increase.
resting energy expenditure (REE)
the amount of energy expended by a person at rest.
-Body size and composition have the greatest effect.
-Many forms of stress on the body can increase REE.
Coenzyme A aids in the transfer of fatty acids from the cytoplasm to mitochondria. It is derived from:
Vitamin B5
Fatty acids are broken down to acetyl- CoA by means of beta oxidation insude the mitochondraia, whereas fatty acids are synthesized from acetyl- CoA outside the mitochondria, in the cytosol.
All of the following factos may help activate BDNF production except
a. curcumin supplementation
b. exercise
c. meditation
d. increased caloric intake
d. increased caloric intake
THESE ALL DO!
a. curcumin supplementation
b. exercise
c. meditation
The gene that turns on BDNF production is activated by several factors. These include calorie restriction, curcumin, docosahexaenoic acid, intermittent fasting, exercise, intellectual stimulation and meditation.
Allostasis is achieved by: automatic processes with which the body reponds to stressors in order to regain homeostasis.
The autonomic nervous system
HPA Axis hormones
cytokines.
Somatic nervous system
Part of the peripheral nervous system associated with the voluntary control of body movements via skeletal muscles.
Which of the following lipoproteins contain the most protein?
1. IDL; 2. Small VLDL particles; 3. large VLDL particles; 4. HDL
HDL
The ratio of protein to fat determines the density, thus particles with high levels of protein are the most dense.
Metabolic alkalosis
increase in serum bicarbonate (alkaline)
Hormones release to raise blood glucose, increase metabolism, constrict certain blood vessels?
epinephrine and norepinephrine
-play a role in the bodies fight or flight response.
Hormones signals the kidneys to reabsorb more sodium
aldosterone
Adrenal glands will secrete aldosterone to signal the kidneys to reabsorb more sodium in order to increase blood pressure.
daily protein requirement for first year?
1.6 g/kg
Recommended protein intake from birth to 6 months averages 2.2 g of protein per kg of body weight.
6-12 months: 1.6 g of protein per kg
daily intake requirements increase during pregnancy for…
Vitamin C, manganese, selenium
Osteoblasts take part in:
- Synthesis of collagen
- secretion of cytokines
- mineralization
Osteoclasts breakdown bone via secretion of enzymes and acid.
Preferred fuel for enterocytes?
Glutamine : an amino acid important for gut and immune health. GLutamine helps maintain the barrier between the inside of the intestines and the rest of the body, protecting against intestinal permeability (leaky gut).
L-glutamine
Acetate and Butyrate are classified as:
Short chain fatty acids (SCFA) are produced by bacteria in the colon. SCFA’s fatty acids with less than six carbon atoms.
typical metabolic change during pregnancy for women of normal weight?
- Visceral fat accumulation may increase as pregnancy progresses.
- Insulin sensitivity in early pregnancy
- Hyperlipidemia
Protein synthesis DOES NOT increase in first trimester. It increases in second and third trimester.
In the first step of gluconeogenesis, pyruvate carboxylase requires.
Biotin:
Gluconeogenesis: the metabolic pathway, synthesis of glucose from the three and four carbon molecules, such as pyruvate.
Site of release for GABA
central nervous system
Gamma-Amino Butyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system.
Antecedents
congenital or developmental aspects of the individual that can include gender, family history, and genomics. These act to set the stage for the body’s response to the trigger.
Prryoloquinoline quinone (PQQ)
redox cofactor. beneficial in treating conditions that involve low mitochondrial function including in aging and neurological disease.
- reduce inflammation based on c-reactive protein levels
- sources include parsley, kiwi fruit, papaya
- support mitochondrial function
Folate absorption takes place in the:
jejunum : the part of the small intestine between the duodenum and ileum
hormone is secreted by the beta cells in the pancreas?
Insulin: regulates the amount of glucose in the blood.
Epidemiology
Studying the incidence, distribution, and possible control of certain diseases in certain populations.
The following proteins are considered essential amino acids (9)
- Phenylalanin
- Valine
- Tryptophan
- Threonine
- Isoleucine
- methionine
- Histidine
- leucine
- lysine
(10). Arginine (some sources)
Essential amino acids are amino acids that need to be supplied by the diet becuase the body CAN NOT make them.
Non-essential amino acids
asparagine
glycine
serine
Involved in normal glucose homeostasis
- Insulin and glucagon
- growth hormone
- corticosteroids
Mineralocorticoids ( produced in the adrenal cortex and influence salt and water balance)
Fructose
may increase urinary excretion of calcium and oxalate
may increase the production of uric acid
may increase insulin resistance
Only carbohydrate known to increase production of uric acid and urinary excretion of uric acid
Which nutrient is responsible for the color of brown adipose tissue (BAT)
Iron: gives brown adipose Tissue
BAT plays a role in body heat and controlling energy expenditure.
Null hypothesis
There is no difference between the 2 groups
Kidneys play an important role in the production and/or elimination of all of the following
vitamin D, calcium, phosphorus
Kidneys play an important role in the maintenance of calcium-phosphorus homeostasis which also involves the production of the active form of vitamin D
fuel source for coloncytes
Butyrate
healthy gut flora digest food through fermentation. When they ferment certain types of fiber, they create butyrate.
Potential risk factors for developmental birth defects
- parental drug use
- hypoxia during pregnancy
- iodine deficiency during early pregnancy
The age of the mother is considered a factor for the development of birth defects, not the father.
All of the following can stimulate the release of glucagon
increased plasma amino acids
increased CCK
Increased norepinephrine
Glucagon is responsible for making sure blood glucose levels arent too low by getting glucose out of the cell. For example, the breakdown of glycogen to glucose in the liver
Athletes who train early in the morning before eating or drinking are at risk for
Low liver glycogen stores
How do lipid soluble compounds enter the intestinal cells from the brush border?
passive diffusion moves nutrients from a high concentration to an area of lower concentration.
nutrient deficiency is most closely associated with hearing loss in aging adults?
Vitamin B12 (depleted stomach acid levels)
Vitamin B12
Dependent methionine synthase catalyses the conversion of 50methyltetrahydrofolate and L-homocysteine to tetrahydrofolate and L-methionine as the final step. The enzyme requires B12 (methylcobalamin)
Ph for Salivary amylase:gastric pepsin
salivary amylase (6.75-7.00)
Gastric pepsin and lipase (1.5-3.5)
Extremes of PH can lead to denaturation of enzymes
Resting MEtabolic Rate (RMR) was approximately 1,246 calories and activity factor (1.375) = total energy expenditure
TEE is calculated by multiplying RMR and activity factor
1,246 x 1.375= 1,713
amino acids and ions absorbed ?
active transport moves against concentration gradient which requires a carrier protein and uses ATP
average caloric intact for infants (first 6 months)
108 calories
An infant will consume adequate amounts of nutrients and calories if breastfed. The range in caloric requirements for individual infants is braod, ranging from 80 to 120 calories per kg (2.2 lb body weight) Average: 108
calories from fat, carbohydrates, protein
fat (9 calories)
carbohydrates (4 calories)
Protein (4 calories)
example: 18 grams fat, 100 grams carbohydrates, 40 grams protein
18x9+ 4x100+ 4x40= 722
Which of the following diseases causes a defect in copper metabolism?
Menke’s disease (MNK) : recessive disorder caused by mutations in genes coding for the copper transport protein.
client is 28 year old female who just had a baby. So far, she has lost 8 lbs. Before she got pregnant, she was 125 lbs. How much weight can she expect to lose within a week after delivery?
15 pounds within the first week after delivery.
Loss of more than 1.5 pounds per week, even in women with excess fat stores, can decrease breast milk production.
hepicidin synthesis is increased by
iron loading
Hepicidin synthesis increases in response to iron and inflammation and decreases in response to erythropoiesis.
Diet, medication compliance, and sleep hygiene are examples of which type of health related factors?
behavioral (indicate an individuals direct actions related to their health)
Environmental factors consist of the physcial (natural and built) environmental surrounding an individual, not their actions.
what is needed for short chain fatty acid synthesis in the colon
fiber (bacteria in the colon feed on fiber to produce short chain fatty acids)
wo carbon omega 6 fatty acid with 4 double bonds (20:4)
ARA (Arachidonic acid is a polyunsaturated omega 6 fatty acid)