Glucose Regulation Flashcards
What causes T1DM
Destruction of beta cells of the islets of Langerhans which are the cells that make insulin.
What’s the difference between basal and bolis beta cells?
Basal cells gmaintain Blood glucose while we are not eating, and bolus cells regulate blood glucose in response to food. (They are also increased 10 mins before eating)
What’s the difference between Type 1 DM and T2DM?
Type 1 is insulin dependent and type 2 is insulin resistant
What ethnic group is more at risk for undiagnosed diabetes and why?
Native Americans because they live on their own reservation so they do not always have access to important health care.
DM is the leading cause for what following things in the US?
- New cases of blindness
- End stage kidney disease. Requiring dialysis or kidney transplant
- Lower extremity amputation
- ER visits for hypoglycemia and hyperglycemia
What is an early sign for diabetes?
Increased thirst
What are the symptoms of hyperglycemia
- Feeling hungry
- Blurry vision
- Frequent urination
- High blood sugar
- Tingling limbs
- Feeling thirsty
What are some atypical presentation of hyperglycemia in the elderly?
- A sense of not feeling oneself
- Electrolyte imbalance and dehydration
- Incontinence
- Appetite loss (due to depression, GI disease, of drug side effects)
- Fatigue and gradual profound loss
Signs and symptoms of hypoglycemia
- Sleepiness
- Sweating
- Pallor
- Lack of coordination
- Irritability
- Hunger
What are some causes of hypoglycemia reactions
Too much insulin, too little food, increase exercise without food.
What are some home management interventions for hypoglycemia?
10-15 carbs, recheck BG in 15 min and repeat. Eat a small carb and protein snack if next meal is more than an hour away
What are some moderate hypoglycemia (<40) home management interventions?
15-30 carbs plus low-fat milk or cheese after 10-15 min. Recheck BG in 15 min. Pop that is not diet will give you about 15 grams of carbs
What are some interventions for for severe hypoglycemia (<20) (unconscious)
Glucagon 1 mg IM or Sub Q, administer a second dose in 10 min if remains unconscious, notify the provider and transport to ER. Conscious pt give a small meal if not nauseated
How does someone get diagnosed with diabetes?
1, hemoglobin A1C is greater than of equal to 6.5%
- Fasting blood glucose is greater than or equal to 126 mg/dL
- 2- hour plasma glucose is greater than of equal to 200 mg/dL in the 75 g OGTT
- Signs and symptoms of hyperglycemia and random plasma glucose greater than or equal to 200 mg/mL
- In the absence of hyperglycemia, confirmed by repeat testing
What are the diagnostic tests to test for diagnostic?
- Fasting blood glucose
- No calorie intake for 8 hours
- Oral glucose tolerance test
- Glycosylaged hemoglobin
- C-peptide
- Urine tests