Glucose And Glycolyisis Flashcards
How does the Sodium gluose transporter work
iTunes the [] gradient for sodium inwards into the cell to provide the energy to drive glucose up its concentration gradient from a low [] gradient t hig in the epithelial cells
What is produced from glycolysis ?
NADH
2 ATP net (uses 2)
C6 and c3 intermediates
Features of glycolysis
Ecergonic Oxidative Occurs in all tissues cytosolic Can operate anaerobically Irreversible C6 to 2c3
What enzymes are involved in glycolysis and what do they do
Hexokinase- glucokinase in the liver -
- converts gluose to glucose 6P
Phosphofructokinase-1
-key control enzyme
Converts fructose-6-P to fructose 16 bisphosphate
Pyruvate kinase
-converts Phosphoenolpyruvate to pyruvate
Which stages of glycolysis are irreversible?
1,3 and 10
Step 3 is the committing step- the rate limiting step
what organs can metabolise lactate into pyruvate
the liver and kidney: this allows pyruvate to go through gluconeogenesis to form glucose. Glucose can feed into glycolysis, be fed into circulation, or be used for storage
In the heart|: pyruvate is oxidised directly for energy
What are the three key enzymes in glycolysis?
Hexokinase
pyruvate kinase
Phosphofructokinase-1
what is the rate limiting enzyme of glycolysis
phosphofructokinase