GI system disorders Flashcards

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1
Q

What makes up the upper GI tract

A
  • mouth,
  • esophagus
  • stomach
  • duodenum
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2
Q

What makes up the lower GI tract

A
  • small and large intestines
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3
Q

What are the effects of aging on the GI tract

A
  • tooth decay/loss
  • lose motility in GI tract = constipation
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4
Q

S&S of GI disease

A
  • nausea&vomiting (upper GI)
  • abdominal pain
  • Diarrhea, constipation and fecal incontinence (lower GI)
  • achalasia: difficulty with esophageal emptying (autoimmune or innervation)
  • GI bleeding (typically found in the stool)
  • Dysphagia: difficulty swallowing
  • anorexia and anorexia-cachexia
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5
Q

Hiatal Hernias

A
  • when the esophageal hiatus of diaphragm becomes enlarged it allows the stomach to pass through into the thoracic cavity
  • can be congenital or acquired
  • acquired can be sliding or paraesophogeal
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6
Q

How do sliding hiatal hernias form

A
  • there is widening of the hiatal tunnel around esophagus
  • increased abdominal pressure such as straining, acid reflux, vomiting can allow the gastoresophageal junction to pass above diaphragm
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7
Q

How do paraesophageal hernias develop

A
  • secondary due to surgery or trauma
  • associated with laxity of gastrophrenic and gastrocolic ligaments
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8
Q

What are lower abdomen hernias

A
  • indirect inguinal: most common, congenital or acquired, intestine protrudes into the inguinal canal
  • direct inguinal: acquired from lifting or straining; goes through inguinal ligament
  • Femoral: loop of intestine goes through the femoral ligament
  • umbilical: Goes through the abdominal muscle
  • incisional: goes through an incision
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9
Q

Signs and symptoms of hernias

A
  • heart burn
  • difficulty swallowing
  • treatment is to stay elevated especially after eating
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10
Q

Gastritis:

A
  • inflammation of the stomach
  • diagnosis of exclusion of other conditions
  • often follows infection
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11
Q

Gastritis: pathophysiology/S&S

A
  • Inflammation of the stomach lining
  • acute or chronic
  • associated with H pylori, ulcers and cancers
  • epigastric pain with feeling of distention
  • loss of appetite
  • nausea
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12
Q

Gastritis: management

Dx/Tx

A
  • H pylori breath test
  • blood teat
  • stool test
  • upper endoscopy
  • Upper GI test
  • Tx: depends on the cause
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13
Q

Peritonitis:

A
  • peritoneum
  • can be caused if appendicitis ruptures
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14
Q

Peritonitis: pathophysiology/S&S

A
  • inflammation of serous membrane lining walls of abdominal cavity
  • forms adhesions and causes destruction
  • decreases intestinal motility and causes intestinal distention with gas
  • initially presents with fatigue and generalized abdominal pain
  • progress to acute abdomen and severe abdominal pain
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15
Q

Peritonitis: management

Diganosis and treatment

A
  • abdominal exam
  • blood test
  • paracentesis
  • tx: antibiotics surgical drainage and debridement and supportive measures
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16
Q

Appendicitis: S&S

A
  • abdominal pain (RLQ) with anorexia
  • nausea/vomiting
  • low-grade fever
  • RLQ point tenderness at McBurney’s point
  • pinch inch test: for peritonitis if pain when skin fold strikes the peritoneum
  • elevated WBC >20,000 mm3 suggests rupture
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17
Q

Appendicitis: management

A
  • US
  • CT scan
  • Tx: surgery
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18
Q

Cholecystitis

A
  • inflammation of the gallbladder
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19
Q

Cholecystitis: pathophysiology/Symptoms

A
  • gallstones
  • tumor
  • blockage of bile duct
  • infection
  • illness

Symptoms

  • serere pain in your upper right of center abdomen or right shoulder of back
  • tenderness over your abdomen when its touched
  • nausea/vomiting
  • fever
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20
Q

Cholecystitis management

A
  • US
  • CT scan
  • HIDA scan: tip the person and take a scan
  • tx: weight loss, diet, surgery
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21
Q

Esophageal cancer S&S

A
  • dysphagia with or without pain
  • weight loss
  • scapular pain
  • more common with those with GI history
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22
Q

esophageal cancer incidence

A
  • one of the lowest cure rates
  • 5 yr survival 10%
  • median survival <10 months
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23
Q

esophageal cancer linked to

A
  • linked to H pylori
  • squamous cells (90% worldwide)
  • adenocarcinoma
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24
Q

Gastric adenocarcinoma S&S

A
  • weight loss
  • abdominal pain
  • early satiety
  • hurts to eat
25
Q

Gastric adenocarcinoma management/survival rate

A
  • endoscopic screening (not done unless you have symptoms)
  • 5 year survival rate 31%
  • most common
26
Q

Gastric adenocarcinoma: associated with

A
  • H. pylori
  • epstein barr virus
27
Q

Colorectal cancer risk factors

A
  • 1st degree relative had it
  • cigarette smoking
  • alcohol consumption
  • age
  • male gender
  • H/O polyps
  • polyps take 10-15 years to become cancerous
28
Q

Colorectal cancer survival

A
  • 4 leading cancer deaths
  • 5 year survival
  • 64% overall
  • 90% with early detection
29
Q

colorectal pathophysiology

A
  • begins as a polyp
  • takes 10-15 years to become cancerous-
30
Q

GERD

A
  • gastroesophogeal reflux disease
  • esophagitis
31
Q

Causes of GERD

A
  • chocolate
  • peppermint
  • fatty foods
  • citrus products
  • spicy foods
  • coffee
  • carbonated drinks
  • alcohol
  • caffeine
  • nicotine
  • CNS depressants
  • prolonged vomtiing
  • pregnancy (last trimester)
32
Q

GERD symptoms

A
  • 30-60 minutes after a meal
  • heartburn
  • reflux
  • belching
  • dysphagia
  • painful swallowing
  • burning sensation that may move up and down back, neck, jaw (mimics MI)
33
Q

Complications of GERD

A
  • esophagitis
  • barrets esophagus
  • strictures: constant inflammation leads to fibrous tissue = narrowing of esophagus = cancer
  • adenomcarcinoma
34
Q

Barrett’s esophagus

A
  • esophagus becomes damaged due to prolonged acid exposure
  • esophagus starts to fill with stomach cells that are abnormally being laid down
35
Q

Management of GERD

A
  • antacids: magnesium hydroxide, aluminum hydroxide (taking too many = make sure they are seeing their doc)
  • histamine 2 blockers: block release of acid into stomach
  • proton pump inhibitors: omeprazole, Prilosec, aciphex, prevailed, Nexium (blocks release of acid into stomach)
36
Q

Peptic ulcer disease

A
  • break in mucosal lining exposing submucosal area to gastric sections
  • gastric ulcer = lining of stomach often relieved by eating g
  • duodenal ulcer - duodenum = feels better 45 minutes after eating
  • stress (secondary ulcers)
37
Q

Meds for peptic ulcers

A
  • drugs that reduce intragastric ulcers: antacids, H2 receptor blockers, Proton pump inhibitors, antimuscarinic drugs
  • drugs that promote mucosal defense against acid erosion: bismuth compounds (pesto, kaopectate)
  • Drugs that eradicate the bacterium (helicobacter pylori, antibiotics)
  • avoid spicy foods
38
Q

Prokinetic meds for the GI system: how they stimulate motor function

A
  • lower esophageal sphincter pressure
  • improve gastric emptying
  • stimulate small intestine
  • accelerate colonic transition
39
Q

Clinical indications for prokinetic meds

A
  • GERD
  • gastroparesis: paralysis of stomach
  • post-op ileus
  • constipation
40
Q

Other meds for GI system

A
  • antidiarrheals: lopermide, bile salt binding resins
  • constipation: (opioids can cause) laxatives, stool softener (usually given with opioids), osmotic laxatives
  • antispasmodics (anticholinergics): ADRS, used infrequently
  • 50HT3 receptor antagonists
41
Q

Irritable Bowel Syndrome

signs and symptoms

A
  • > 3 months of abdominal pain with at least 3 other symptoms
  • abdominal bloating or distention
  • passage of muscus
  • changes in stool form
  • changes in frequency
  • difficulty passing a movement
42
Q

Irritable bowl syndrome
- pathophysiology

A
  • altered GI motor activity
  • visceral hypersenitivity
  • altered processing of info by nervous system,
  • altered intestinal microflora
  • increased intestinal permeability
43
Q

Irritable bowl syndrome

Treament

A
  • TCA
  • serotonin-modulating agents possible
  • treat symptoms
44
Q

Celiac disease

What is it?

A
  • malabsorptive disorder
  • immune mediated disorder that is trigger by gluten
45
Q

Celiac disease

clinical manifestations

A
  • vary
  • diarrhea
  • bloating
  • indigestion
  • flatulence
  • weight loss
  • abdominal cramping
  • dermatitis herpetiformis
46
Q

Celiac disease

management

A
  • gluten free diet
  • IgA indicates this as well as some other proteins
  • adverse effects: coagulation and infertility
47
Q

Crohns disease

what is it

A
  • inflammatory bowl disease
  • any segment can be affected (large intestine)
  • presents earlier in life
  • all layers of intestinal wall can be involved
48
Q

Crohns disease: pathophysiology

A
  • granulomas
  • thickened bowl wall
  • narrow lumen
  • fissures and fistulas
49
Q

Crohns disease: clinical manifestations

A
  • abdominal pain
  • right lower quadrant mass
  • severe anorexia and weight loss
  • skin rashes
  • joint pain
  • marked retardation of growth (peds)
  • remission and exacerbations
50
Q

Ulcerative colitis: what is it

A
  • doesnt typically occur until lateral on
  • inflammatory bowel disease
  • Rectum and colon affected
  • muosal layers and submucosal layers
51
Q

Ulcerative colitis: clinical manifestations

A
  • abdominal pain
  • diarrhea and blood stool
  • mild-moderate anorexia and weight loss
  • skin rases
  • joint pain
  • remissions and exacerbations
  • cancer is common
52
Q

Inflammatory bowel disease meds

A
  • aminosalicylates
  • clucocorticoids
  • methotrexate
  • purine analogs
  • anti-TNF agents
  • monoclonal antibiodies
53
Q

Diverticular disease

A
  • diverticulosis: uncomplicated
  • diverticulitis: inflammatory
  • most common in signmod colon
  • littel pouches in the colon where things can get stuck
54
Q

Diverticular disease: clinical manifestations

A
  • pain in LLQ (differentiate between iliopsoas)
  • can cause a systemic infection (peritonitis)
  • things do not digest well as they get stuck in the pouches
55
Q

Intestinal ischemia: what is it and types

A
  • decrease blood supply to bowel
  • Acute mesenteric: life threatening
  • chronic mesenteric: aka intestinal angina/followed and managed
  • colonic ischemia
56
Q

Intestinal ischemia: clinical manifestations

A
  • abdominal pian
  • things get stuck and can get infected
57
Q

Rectal fissure

A
  • a cut
  • ulceration or tear of lining in the anal canal
  • childbirth of large hard bowl movement can cause it
  • heal iwthin a month or two
58
Q

Rectal abscess and fistulas

A

infected anal gland, fissure or prolasped hemorrhoid

59
Q

Hemorrhoids

A
  • can be hereditary
  • varicose veins just beneath the mucous membrane lining the rectum and anus
  • caused by anything that increases intraabdominal pressure
  • internal - lower rectum; blood in stool, caused by straining
  • external: under skin around anus; bleed in injured or ulcerated; painful