GI pathology

Question 1

Discuss Bulemia:

• What is it?
• ______ enlargement due to nutritional deficiency
• What is the cardinal sign of bulemia?

Answer 1

Bulemia

• Patient consumes large volumes and vomits
• Parotid enlargement due to nutritional deficiency
• Cardinal sign: severe erosion of enamel along lingual surface of maxillary teeth

Question 2

Discuss Gardner’s syndrome:

• What is it?
• What is the most common bone lesion associated with Gardner’s syndrome?
• What are oral clinical features of Gardner’s syndrome?

Answer 2

Gardner’s syndrome:

• Intestinal polyposis, premalignant variant (adenomatous)
• Osteomas
• Supernumerary teeth, unerupted/impacted teeth

Question 3

Discuss Plummer-Vinson Syndrome:

• _____ is the hallmark of disease from esophageal stricture or webs
• ____ deficiency
• What are the clinical oral manifestations?
• Cancer?

Answer 3

Plummer-Vinson Syndrome

• Dysphagia (difficulty swallowing) is hallmark of disease from esophageal stricture or webs
• Iron deficiency anemia
• Atrophic glossitis, thinning of vermillion borders and leukoplakia
• Oral squamous cell carcinoma reported in about 10% of cases

Question 4

All of the following are characteristic of Plummer-Vinson Syndrome EXCEPT:

A. Parotid enlargement due to nutritional deficiency

B. Dysphagia is a hallmark of disease from esophageal stricture or webs

C. Iron deficiency anemia

D. Atrophic glossitis, thinning of vermillion borders and leukoplakia

E. Oral squamous cell carcinoma reported in around 10% of patients

Answer 4

A. Parotid enlargement due to nutritional deficiency

Bulemia = parotid enlargement due to nutritional deficiency

Question 5

All of the following are characteristic of Gardner’s syndrome EXCEPT:

A. Intestinal polyposis

B. Osteomas

C. Supernumerary teeth

D. Atrophic glossitis, leukoplakia and thinning of vermillion border

E. Unerupted/impacted teeth

Answer 5

D. Atrophic glossitis, leukoplakia and thinning of vermillion border

note: atrophic glossitis and leukoplakia are characteristic of Plummer-Vinson syndrome

Question 6

Discuss Sjogren Syndrome:

• What is it?
• What occurs to cause the progressive drying out of tissues?
• What are the typical symptoms seen?
• Patients with Sjogren syndrome have an increased risk (40x) of ______.
• What are the systemic diseases associated with Sjogren syndrome?

Answer 6

SJogren Syndrome:

• an inflammatory disease of exocrine glands
• Autoimmune destruction of exocrine glands (salivary and lacrimal glands)
• Dry eyes and mouth (xerostomia)
• Increased risk of lymphoma
• Systemic diseases associated:

1. Fatigue
2. Arthralgia/Myalgia
3. Gland enlargement
4. Raynaud phenomenon (discoloration of digits)
5. Vasculitis
6. Peripheral neuropathy
7. Oral changes

Question 7

All of the following are oral manifestations of Sjogren Syndrome EXCEPT:

A. Atrophic papillae, deeply fissured epithelium

B. Angular cheilitis

C. Missing teeth and multiple caries

D. Warthin’s tumor

E. Atrophic glossitis

Answer 7

E. Atrophic glossitis

Question 8

_______ is one of the most common malignant salivary gland tumors that usually involves the parotid gland.

Answer 8

Mucoepidermoid Carcinoma