GI Infections Pathogens Flashcards

1
Q

What is normal flora

A

beneficial/good bacteria ]not all colonisation is normal

begins at birth

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2
Q

What traits increase an invading organisms chance of success

A

High growth rates
Dispersal capability
Phenotype plasticity
Genetic diversity

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3
Q

Stages of invasion

A

Introduction -to a new environment/community
establishment-and maintenance of a viable invader
growth and spread-upon the acquisition of resources
impact - of varying consequences

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4
Q

Where are new pathogens colonised

A

In the tissue under the epithelial cells

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5
Q

What does colonisation mean

A

The establishment of a microorganism within or on a host - may be short lived

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6
Q

What is a pathogen

A

Any microorganism the potential to cause disease

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7
Q

What happens in the incubation period

A

Pathogen replicates in host

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8
Q

What immune system components target bacteria

A

Phagocytes
Antibodys and B lymphocytes
Complement proteins

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9
Q

What immune system components target viruses

A

T lymphocytes

antibodies and B lymphocytes

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10
Q

What immune system components target fungus

A

Eosinophils
T lymphocytes
Phagocytes

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11
Q

What immune system components target protozoa

A

T lymphocytes

Eosinophils

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12
Q

What immune system components target worms

A

Eosinophils

Mast cells

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13
Q

What colour to gram +ve bacteria stain and why

A

PURPLE

peptidoglycan wall traps crystal violet dye

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14
Q

What colour do gram -ve cells stain and why

A

PINK

no peptidoglycan wall to trap crystal violet dye so it is easily washed away

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15
Q

What are enterobacteriaceaec

A

Gram negative rods
Non spore forming
Ferment sugars

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16
Q

How do enterobacteriaceae cause disease

A

Motility - flagella (lash like appendage) allows movement
Fimbriae help colonisation by binding tight to tissue
Endotoxin

17
Q

What two enterobacteriaceae non-mobile

A

shigella and klebsiella

18
Q

What is MALDI-TOFF mass spectrometry

A

Analyses protein component of bacteria cell wall
Compares with a data base
Differentiates between highly similar organisms
Can tell if a bacteria is pathogenic or non pathogenic

19
Q

Steps to identify enterobacteriaceae

A

Collect appropriate clinical sample
Perform gram stain
Lab selects appropriate biochem tests
report results to clinicians

20
Q

What is the normal flora in the mouth

A

Strep “virdans”
Neisseria sp
Anaerobes candida sp
Staphylococi

21
Q

What is the normal flora of the stomach/duodenum

A

Low pH
Usually sterile
Few candida and staphylococci may survive

22
Q

Normal flora of the jejunum

A

small numbers of coliformas and anaerobes

23
Q

Normal flora of the colon “faecal flora”

A

Large numbers of coliforms, anaerobes and enterococcus faecalis

24
Q

Normal flora of the bile ducts

A

Sterile

25
Q

Anaerobes of the GI tract

A

Strict anaerobes- will not grow in presence of oxygen
Clostridium
Bacteroides
Anaerobic cocci
present in large numbers in the large bowel