GI Immunology

Question 1

Define innate immune system

Answer 1

A universal and evolutionary conserved system of host defence

Question 2

Define the adaptive immune system

Answer 2

Induced upon infection by specialised pathogens

Question 3

What is the relationship between the colonic mucosa and immunity ?

Answer 3

The colonic mucosa gives us a physiological immunity

Question 4

Define self-tolerance

Answer 4

We learn to mot attack our own cells

Question 5

Define exogenous tolerance

Answer 5

We develop an ability to determine which environmental antigens are trying to causes us harm and which are not

Question 6

Define effective immune response

Answer 6

Our immune system know when to attack and eliminate infectious or toxic agents

Question 7

What are cytokines and what is their function ?

Answer 7

Mediators of the immune system They are anti-inflammatory

Question 8

What are T-cells and what is their function ?

Answer 8

Can be either pro-inflammatory or anti-inflammatory

Question 9

What is a peyers patch ?

Answer 9

A large group of immune cells which is often found within the gut, it contains antigen presenting cells.

Question 10

IBD is a result of ?

Answer 10

Leaky epithelial barrier in which bad bacteria can cross this barrier and cause inflammation

Question 11

Name 3 signals that determine T-Cell response

Answer 11

MHC/peptide-TCR
CD80-CD28
Cytokines

Question 12

Name 3 T regulatory cells

Answer 12

Th3, Tr1 and Treg

Question 13

Name 3 T helper cells ?

Answer 13

Th1, Th2 and Th17