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Drug Info > GI Drug Facts > Flashcards

GI Drug Facts Flashcards

1
Q

Clinical term for heartburn

A

gastroesophageal reflux disease

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2
Q

What helps the tablet pass through the stomach?

A

Enteric-coating

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3
Q

What is acid-labile?

A

compound that is destroyed by acid

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4
Q

dosage form of Prilosec (Rx)

A

delayed-release capsule

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5
Q

dosage form of omeprazole (Rx)

A

delayed-release capsule

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6
Q

dosage form of Prilosec (OTC)

A

delayed-release tablet

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7
Q

dosage form of omeprazole (OTC)

A

delayed-release tablet

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8
Q

Strengths Prilosec (Rx)

A

10mg,20mg,40mg

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9
Q

Strengths of omeprazole (Rx)

A

10mg, 20mg, 40mg

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10
Q

Indications for PPI’s

A

GERD
erosive esophagitis
gastric ulcers
Zollinger-Ellison Syndrome

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11
Q

What is Zollinger-Ellison Syndrome?

A

A hypersecretory condition where too much gastric acid is produced

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12
Q

Dosing interval for PPI’s

A

Take 1 daily, 30 minutes prior to breakfast. Do not take with food-decreases absorption

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13
Q

Strength of Prilosec (OTC)

A

20mg

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14
Q

Strength of omeprazole (OTC)

A

20mg

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15
Q

Is Prilosec enteric-coated?

A

yes

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16
Q

What is contained in Zegerid?

A

NaHCO3 and omeprazole

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17
Q

Is Zegerid enteric-coated?

A

No

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18
Q

Strength of Zegerid-OTC

A

20mg ompeprazole

1100mg NaHCO3

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19
Q

Strength of Zegerid (Rx)

A

40mg omeprazole

1100mg NaHCO3

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20
Q

What does the NaHCO3 do?

A

neutralizes the gastric acid, providing instant heartburn relief and protecting teh omeprazole of acid degradation

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21
Q

Strength of Zegerid powder for oral suspension (Rx)

A

20mg omeprazole
1680mg NaHCO3

40mg omeprazole
1680mg NaHCO3

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22
Q

What is the mixture of esomeprazole?

A

S isomer of omeprazole

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23
Q

Composition of Nexium

A

gel capsule containing enteric coated granules

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24
Q

Dosing interval for Nexium

A

1 daily

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25
Q

Dosing interval for esomeprazole

A

1 daily

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26
Q

Strength of Prevacid 24 HR

A

15mg

OTC

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27
Q

Strength of Prevacid (Rx)

A

30mg

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28
Q

Strength of Prevacid SoluTab

A

15mg

30mg

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29
Q

Generic for PPI associated with SoluTab

A

lansoprazole

30
Q

Trade name for PPI associated with SoluTab

A

Prevacid

31
Q

Dosing interval for Prevacid

A

1 daily

32
Q

Dosing interval for lansoprazole

A

1 daily

33
Q

Mixture in Dexilant

A

R isomer of lansoprazole (Prevacid)

34
Q

Dosage form of Dexilant

A

delayed-release capsule

35
Q

How does dexlansoprazole work?

A

Dual delayed- release formulation
Some is released for immediate relief
Rest is released 4 hours later
Primarily used for nighttime heartburn(GERD)

36
Q

What PPI would be used for nighttime GERD?

A

Dexilant (dexlansoprazole)

37
Q

Dosage form of Protonix

A

delayed-release tablet

38
Q

Dosage form of AcipHex

A

delayed-release tablet

39
Q

Dosage form of pantoprazole

A

delayed-release tablet

40
Q

Dosage form of rabeprazole

A

delayed-release tablet

41
Q

Indications for sulfasalazine

A

ulcerative colitis

rheumatoid arthritis

42
Q

Indications for Azulfidine

A

ulcerative colitis

rheumatoid arthritis

43
Q

Dosage forms of sulfasalazine

A

Tablet - Azulfidine

delayed-release tablet - Azulfidine EnTab

44
Q

Dosage interval for Azulfidine

A

Three times daily - take with food

45
Q

Dosing interval for Azulfidine EnTab

A

Three times daily

46
Q

What is mesalamine?

A

Active component of sulfasalazine (Azulfidine)

47
Q

Indications for mesalamine

A

ulcerative colitis

48
Q

Dosage form of Asacol

A

400mg delayed-release tablet

49
Q

Dosage form for Asacol HD

A

800mg delayed-release tablet

50
Q

Dosage form of Lialda

A

1.2g delayed-release tablet

51
Q

Dosing interval for Asacol

A

Three times daily

52
Q

Dosing interval for Asacol HD

A

Three times daily

53
Q

Dosing interval for Lialda

A

1 daily

54
Q

Dosage form of Pentasa

A

250mg or 500mg controlled-release capsule

55
Q

Dosing interval for Pentasa

A

4 times daily

56
Q

Dosage form of Apriso

A

0.375g delayed-release/extended-release capsule

57
Q

Dosing interval for Apriso

A

1 daily

58
Q

Dosage form of Canasa

A

1g rectal suppository

59
Q

Dosing interval for Canasa

A

1 daily-Use at bedtime-retain for 1 to 3 hours

60
Q

Dosage form of Rowasa

A

4g/60ml rectal suspension for enema

61
Q

Dosing interval for Rowasa

A

1 daily-use at bedtime-retain it for 8 hours(overnight)

62
Q

What is the prokinetic aspect of metaclopramide?

A

It increases the upper GI tract motility, causing a reduction in heartburn

63
Q

What is a special warning associated with sulfasalazine and mesoalamine?

A

These drugs are contraindicated for pt’s allergic to aspiriin

64
Q

what two therapeutic categories are associated with metoclopramide?

A

Prokintec/Antiemetic

65
Q

BBW for metoclopramide

A

Chronic use may cause tardive dyskinesia

66
Q

What is tardive dyskinesia?

A

Involuntary, repetitive movements

67
Q

Indications for metoclopramide

A

GERD

nausea/vomiting associated with chemotherapy

68
Q

What is the CTZ?

A

Chemoreceptor Trigger Zone - Nausea center in the brain

69
Q

WHat is the Antiemetic aspect associated with metoclopramide?

A

blocks seretonin receptors in the CTZ in teh brain, reducing nausea and vomting.

70
Q

Dosing interval for metoclopramide(Prokinetic)

A

4 times daily

71
Q

Dosing interval for metoclopramide(Antiemetic)

A

Take 30 min. before chemotherapy, then every 2 to 3 hours after therapy as needed

72
Q

Dosage forms of metoclopramide

A 
tablet (5mg, 10mg)
oral solution (5mg/5ml)

Drug Info (21 decks)

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