GI

Question 1

Where are chylomicrons synthesized?

Answer 1

enterocytes synthesize chylomicrons from dietary lipids absorbed in the intestine. These are excreted into the lymphatics and enter the bloodstream via the left subclavian vein

Question 2

reduces availability of LDL for macrophages

Answer 2

HDL
within macrophages, LDL is oxidized by superoxide radicals, NO, H2O2
LCAT locks cholesterol into the HDL core by converting it to cholesterol ester

Question 3

Apoproteins recognized by the LDL receptor

Answer 3

ApoB100

ApoE

Question 4

drug that reduces intestinal absorption of free cholesterol

Answer 4

ezetimibe

Question 5

remethylation of homocysteine forms what?

Answer 5

methionine
requires B12
The cystathionine pathway for conversion of homocysteine to cysteine requires B6.

Question 6

composed of ApoE

Answer 6

VLDL
HDL
IDL
chylomicron remnants