General Review Set 2 Flashcards
What is the purpose of the Anion Gap?
Assess origin of metabolic acidosis by differentiating between gain in acid or loss of buffer
What are the general principles that would explain the abnormal conditions that would lead to a metabolic acidosis? (2)
- Net gain of fixed acids (increased production or decreased removal aka renal failure or disease)
- Reduction of buffer base (loss of bicarb via diarrhea)
How is the anion gap measured?
Comparing the difference between major measured cations (Na+) and major measured anions (Cl- + HCO3-) showing the amount of unmeasured anions
- Na - (cl + HCO3)
- Normal = 9-14 mmol/L
- A balance would have a net neutral charge
Why does a normal anion gap metabolic acidosis cause fluid shifting?
When excessive bicarb is lost, an anion is lost (loss of negative charge) resulting in a chloride shift from intracellular to extra cellular spaces to maintain electroneutrality
- Hyperchlormic imbalance causes fluid shifting (NAGMA)
- recall the law of electroneutrality; they will shift to ensure balance.
What is the formula to calculate PaCO2 to compensate for metabolic acidosis?
PaCO2 = ([1.5xHCO3] + 8) +/- 2
what happens with a High Anion Gap Metabolic Acidosis (HAGMA)?
- Excessive fixed acids are produced (or ingested), the fixed acids dissipate in the blood into an acid (+ charge) and base (- charge) pair
- The acid is buffered by bicarb while the base remain = high anion gap with decreased bicarb (balances out with lower values)
- just focus on the bolded bit
What factors may be helpful in recognizing a Myocardial Infarction (MI)?
Cardiac markers; there are more factors but these are good indicators from a blood gas
- Troponin I
- Creatine Kinase (CK)
- Myoglobin
- B-type Natriuertic peptide (NMB)
What cations and anions would be in the intracellular fluid?
- Cations = K+ and Mg++
- HPO4 and SO4
What cations and anions would be in the extracellular fluid?
- Cations = Na, K, Ca, Mg
- Cl, HCO3, Lactate
What is Diabetic Ketoacidosis (DKA)
In the absence of sufficient insulin, particularly in type 1 diabetes, the body breaks down fat for energy, producing ketones and leading to DKA, a potentially life-threatening condition
- A complication of diabetes, type 1 is more common than type 2
- Occurs when there is a culmination of keytones as a resulting in metabolic acidosis
What are keytones
Keytones are a byproduct of the use of fat as an energy source (rather than glucose and ATP); they are formally produced but the liver.
- Culmination of keytones can result in metabolic acidosis
How does Diabetic Ketoacidosis differ between type 1 and 2 diabetes?
- Type 1 is primarily due to insulin deficiency
- Type 2 is often triggered by severe metabolic stress or relative insulin deficiency
Without insulin, would a body become hyperglycaemic or hypoglycaemic.
Hyperglycaemia would occur because glucose can’t enter the cells for energy without insulin.
- Insulin promotes uptake of glucose into cells, especially muscle and adipose tissue.
What is type 1 diabetes?
An autoimmune condition where the pancreas produces little to no insulin.
- leads to high blood sugar
- requires insulin admin
What is type 2 diabetes
Insulin resistance and relative insulin deficiency
- lifestyle choices are the cause and management involves lifestyle changes, oral meds, and insulin therapy in some cases
What are the primary functions of insulin
Regulation of blood glucose levels by:
- Facilitating uptake of glucose into cells (and storage) which lowers it
- Enhances utilization by converting by glycosides (glucose to ATP) for energy
Management of anaphylactic shock?
Early Intubation (Airways) and Epinephrine
- Bronchodilators (Ventolin does not fix though)
- Antihistamines
- Corticosteroids
- Fluid resuscitation
Management of neurogenic shock?
Fluid management + sympathomimetic agents (Vasoconstrictiing + Inotropic drugs)
Two mechanisms causing loss of vessel tone in distributive shock?
- Loss of sympathetic control (neurogenic)
- Presence of vasodilator substances in blood (anaphlaytic)
Effect of blood loss on hemoglobin and hematocrit
Decreased hemoglobin and hematocrit
Effect of fluid loss on hemoglobin and hematocrit?
Increased hemoglobin and hematocrit
what drugs would be given for a allergic reaction?
Epinephrine and vasodilators (initially) for severe reactions.
- Prednisone or dexamethasone would be given if the reaction is not severe or an emergency.
- Prednisone and dexamethasone would be continued after the incident to prevent a flare up.
Epinephrine Nebulized dosage?
1mg/ml (1:1000) or 3-5mls
what flow rate is required for Aersolization of medications with a SVN?
6-8 lpm for svn
Management strategy for VCD?
Call speech therapist if you can, but the following can be done:
- 3 sniffs followed by shhh sound
- Give a bento (lorazepam)
- The goal with step 1 is to interrupt autonomic function with higher brain function actions
Why is a FLo2Max special?
Unlike a NRB, the flow can go down to 2lpm.
- Recall that 6lpm is a minimum flow rate for masks to create CO2 washout
How to take HR and RR?
- Count for a full minute
- Count for 30 and x2
- Count for 15 and x4