General Neurophysiology Flashcards

1
Q

production of CSF

A

choroid plexus (50-70%) remaining in the ventricles

  1. passive filtration keeping proteins out
  2. HCO3, K, Cl concentrations controlled by channels on epithelial cells
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2
Q

CSF equal to plasma

A

Na, Cl, HCO3

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3
Q

CSF greater than plasma

A

Mg - due to NMDA R

CO2

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4
Q

CSF less than plasma

A

K - neuronal activity will increase so want low to start
Ca - limit NT release
protein - decrease buffering capacity
glucose - taken up for energy

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5
Q

absorption by arachnoid villi

A

endothelium of sinus and the membrane on the vlli have fused
bulk flow of CSF into venous plexus in the main location
alos pinocytosis

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6
Q

absorption and intracranial pressure

A

proportional
below 68 - none
normal - 112

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7
Q

role of CSF

A

protect the brain

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8
Q

two components that limit exchange

A

tight junctions b/w endothelial cells

glial end feet come in close contact w/ BV increasing diffusion distance

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9
Q

molecules that use passive diffusion across BBB

A

H2O
CO2
O2
free steroid hormones (most are bound)

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10
Q

glucose and BBB

A

cannot freely cross
55K GLUT 1 allows across capillary
45K GLUT 1 allows across astroglia

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11
Q

Na/K/Cl cotrasporter

A

moves all ions from CSF to blood

control K in CSF

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12
Q

drugs and the BBB

A

drugs cross but are moved back into the blood by P-glycoprotein

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13
Q

functions of the BBB

A

protect CSF from blood borne agents
maintain electrolyte composition
protection from toxins
prevent escape of NT

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14
Q

posterior pituitary

A

modified neural tissue that releases hormones into the blood

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15
Q

area postrema

A

will sense blood born substances leading to vomiting

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16
Q

OVLT and subfornical organ

A

control body water/thirst/blood volume so must measure blood osmolarity

17
Q

symp inn arterial blood flow

A

Norepi and NPY
alpha adrenergics
constriction when systemic CO/blood pressure increases

18
Q

parasymp inn arterial blood flow

A

ach, VIP, PHM-27

vasodialation

19
Q

sensory inn arterial blood flow

A

substance p - dilation
neurokinin a - dilation
CGRP - dilation
increase of blood flow will return intracranial volume closer to normal