General Knowledge

Question 1

Route with significant FIRST-PASS effect

Answer 1

Oral

Question 2

Route with significant partial FIRST-PASS effect

Answer 2

Rectal route

Question 3

MC CYP form

Answer 3

CYP 3A4

Question 4

Steps in PharmacoKinetic ProcessS

Answer 4

Absorption
Distribution
Metabolism
Excretion

Question 5

what are the Drug Disposition

Answer 5

DME
Distribution - start
Metabolism
Excretion

Question 6

Drug Elimination commences in what Pharmacokinetic process

Answer 6

Metabolism

Question 7

how many half lives does the drug will reach the STEADY state concentration

Answer 7

3-4 half lives

Question 8

ONLY hormone that is an intracellular receptor but NOT a steroid

Answer 8

Thyroid hormone - proteinaceous

Question 9

Act as inhibitor in the presence of an agonist

Answer 9

Partial agonist

Question 10

binds to different receptor –> produces opposite effect

Answer 10

physiologic antagonist

Question 11

It has a CONSTANT PERCENTAGE drug elimination per time

Answer 11

1st order elimination

Question 12

It has a CONSTANT AMOUNT eliminated per time

Answer 12

Zero Order/ MIchaelis-Menten Kinetics

Question 13

what are the zero order kinetics

Answer 13

WHAT PET
WARFARIN
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline

Question 14

almost CNS anticonvulsant are CYP450 inducers, except

Answer 14

Valproic Acid

Question 15

almost all ANTIBIOTICS are CYP450 Inhibitor, except

Answer 15

Rifampicin
Griseofulvin

Question 16

Phase that tests SAFETY, in Normal healthy volunteer

Answer 16

phase I

Question 17

phase that mainly test EFFICACY in small population with disease

Answer 17

phase II

Question 18

phase with safety and efficacy, and subjected to SPECIAL population (comorbid, child, preg)

Answer 18

Phase III

Question 19

Phase with post marketing surveillance, and mainly test the toxicities

Answer 19

Phase IV

Question 20

Route of administration with NO ABSORPTION with 100% BIOAVAILABILITY

Answer 20

IV route