General Knowledge Flashcards
Route with significant FIRST-PASS effect
Oral
Route with significant partial FIRST-PASS effect
Rectal route
MC CYP form
CYP 3A4
Steps in PharmacoKinetic ProcessS
Absorption
Distribution
Metabolism
Excretion
what are the Drug Disposition
DME
Distribution - start
Metabolism
Excretion
Drug Elimination commences in what Pharmacokinetic process
Metabolism
how many half lives does the drug will reach the STEADY state concentration
3-4 half lives
ONLY hormone that is an intracellular receptor but NOT a steroid
Thyroid hormone - proteinaceous
Act as inhibitor in the presence of an agonist
Partial agonist
binds to different receptor –> produces opposite effect
physiologic antagonist
It has a CONSTANT PERCENTAGE drug elimination per time
1st order elimination
It has a CONSTANT AMOUNT eliminated per time
Zero Order/ MIchaelis-Menten Kinetics
what are the zero order kinetics
WHAT PET
WARFARIN
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline
almost CNS anticonvulsant are CYP450 inducers, except
Valproic Acid
almost all ANTIBIOTICS are CYP450 Inhibitor, except
Rifampicin
Griseofulvin
Phase that tests SAFETY, in Normal healthy volunteer
phase I
phase that mainly test EFFICACY in small population with disease
phase II
phase with safety and efficacy, and subjected to SPECIAL population (comorbid, child, preg)
Phase III
Phase with post marketing surveillance, and mainly test the toxicities
Phase IV
Route of administration with NO ABSORPTION with 100% BIOAVAILABILITY
IV route
