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Pharmacology > CNS drugs > Flashcards

CNS drugs Flashcards

1
Q

Antidote for Benzodiazepine

A

Flumazenil

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2
Q

site of action of Sedative-Hypnotic

A

GABA A receptor

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3
Q

Date Rape Drug

A

Flunitrazepam

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4
Q

most catastrophic symptom of sedative-hypnotic withdrawal

A

rebound suicide

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5
Q

this increases the DURATION of Cl ion channel opening

A

Barbiturates

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6
Q

his increases the FREQUENCY of Cl ion channel opening

A

Benzodiazipine

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7
Q

DOC for seizure in infant

A

Phenobarbital

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8
Q

antidote in methanol and ethylene glycol poisoning

A

Ethanol

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9
Q

DOC for Delireium Tremens

A

Long-acting Benzodiazipine – Diazepam, Chlordiazepoxide

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10
Q

DOC for Opioid overdose

A

Naloxone

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11
Q

DOC for opioid dependence and chronic alcoholism

A

Naltrexone

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12
Q

Sign and symptoms of Delirium Tremens 48-72 hrs post discontinuation

A

Hallucination
Autonomic instability
Delirium

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13
Q

DOC for absence seizure

A

Ethosuximide, Valproic acid

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14
Q

DOC for Myoclonic and Atypical Absence syndrome

A

Valproic acid

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15
Q

Management for Status Epilepticus

A

Phenytoin
Phenobarbital
Diazepam
Lorazepam

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16
Q

DOC for generalized tonic-clonic seziure

A

Valproic Acid
Phenytoin
Carbamazipine

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17
Q

DOC for partial seizure

A

Carbamazepine
Lamotrigine
Phenytoin

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18
Q

DOC for Trigeminal Neuralgia

A

Carbamazepine

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19
Q

Inhibitor of Alcohol dehydrogenase

A

Fomepizole

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20
Q

DOC for Opioid overdose

A

Naloxone

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21
Q

DOC for Opioid dependence and chronic alcoholism

A

Naltrexone

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22
Q

brain change seen in wenicke-korsakoff syndrome

A

hemorrhagic necrosis of the mamillary bodies

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23
Q

MC neurologic abnormality in chronic alcoholics

A

peripheral neuropathy

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24
Q

anti-seizure drug with greatest number of MOA

A

Topiramate - Na, Ca, K, GABA, AMPA-glutamate, carbonic anhydrase

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25
Q

ALL Inhaled anes are bronchodilators, except:

A

Desflurane
C/I in asthma

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26
Q

ALL Inhaled anes are vasodilator except

A

Isoflurane

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27
Q

Inhaled aned with highest potency

A

methoxyflurane
lowest MAC

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28
Q

Has highest MAC but with lowest potency

A

Nitric oxide

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29
Q

Inhaled anes with Punget odor

A

Desflurane
Enflurane

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30
Q

Inhaled anes with Sweet smelling odor

A

Sevoflurane
Halothane

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31
Q

Halothane + Succinlycholine will cause __________

A

Malignant Hyperthermia

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32
Q

Induction agent of choice for unstable patient

A

Etomidate

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33
Q

Local anes with topical use

A

Benzocaine
Tetracaine

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34
Q

antidote for LAST

A

Intralipid

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35
Q

All LA are vasodilator except

36
Q

LA with shortest half life

37
Q

LA with longest half-life

A

Ropivacaine

38
Q

S/E of Prilocaine is methomoglobinemia. what is the antidote

A

Methylene blue

39
Q

Among NMB, Vecurinium has reversal dote

A

Sugammadex

40
Q

Reversal of S/E of Nondepolarizing blockers

A

Neostigmine

41
Q

Drugs used in Lethal injection

A

Pancuronium 100mg
Potassium Cl 100meq
Thiopental 5g

42
Q

Non depolarizing blocker, that is DOC for hemodyanamic compromised

A

Cisatracurium
Vecuronium
Rocuronium

43
Q

Drugs that undergo Hoffman Elimination that yields Laudanosine

A

Atracurium
Cistracurium

44
Q

Treatment for Malignant Hyperthermia

A

Dantrolene

45
Q

IV anes with Adrenocortical suppression

46
Q

a ca channel blocker - blocks RyR1 Ca2 release channels in SR

A

Dantrolene

47
Q

Dopamine precursor

48
Q

Dopamine Agonits, Ergot

A

Bromocriptine - partial agonist at dopamine D2 receptor

49
Q

D2 agonism leads to the inhibition of what hormone

A

inhibition of Prolactin release

50
Q

Agonist at Dopamine D2 receptor

A

Opioid - Apomorphine

51
Q

Side effect of MAO inhibitor

A

Serotonin syndrome

52
Q

Cause Orange urine

A

COMT inhibitor: Tolcapone, -CAPONE

53
Q

Anti viral drug used for parkinson

A

Amantidine

54
Q

Side effect in using Antiviral drug for parkinson

A

Livedo reticularis

55
Q

MAO inhibitors

A

Selegeline, Rasagiline

56
Q

DOC for BIPOLAR disorder

57
Q

Schizo involves in excess activity of dopaminergic neuron in what pathway

A

mesolimbic-mesocortical pathway

58
Q

Positive symptoms in Schizo:

A

HIDES
hallucination
illusion
delusion
excitement
suspiciousness

59
Q

It blocks more D2 receptor > 5HT2a receptor

A

Typical/Classical antipsychotic:
Phenothiazines, Chlorpromazine Thioridazine, Haloperidol

60
Q

Blocks 5HT2A receptor > D2 receptor

A

Atypical Antipsychotic:
Clozapine, Olanzapine, Risperidone, Aripiprazole

61
Q

Typical Antipsychotic with MOST Mucarinic blockade

A

Thiorodazine

62
Q

has the highest potential for EPS

A

Haloperidol

63
Q

DOC for refractory and suicidal schizo

64
Q

Only approves anti-psychotic in schizo in the YOUTH

A

Risperidone, Paliperidone

65
Q

TCA toxicity

A

Coma
Cardiotoxicity
Convulsions

66
Q

DOC for major depressive Disorder

A

Fluoxetine

67
Q

it inhibits neural reuptake of serotonin by inhibiting Serotonin Transporter

A

SSRI
Fluoxetine, Paroxetine, Citalopram, Escitalopram

68
Q

Lethal dose of TCA overdose

69
Q

Toxic dose of TCA overdose

70
Q

Medical management of TCA overdose

A

Bicarbonate

71
Q

SSRI that is only approved for OCD

A

Fluvoxamine

72
Q

Side effect of TCA

A

anticholinergic effects
Histamine block effect
alpha blocking effects

73
Q

SNRI

A

Venlafaxine
Duloxetine

74
Q

drugs can cause Priapism

A

Trazadone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion

75
Q

Tricyclic Antidepressant

A

Imipramine
Clomipramine
Desipramine

76
Q

Tetra Antidepressant

A

Amoxapine
Maprotiline

77
Q

Increases amine release from nerve ending by antagonism of presynaptic a2 adrenoceptors; Blocks serotonin 5HT2 receptor

A

Mirtazapine

78
Q

MAO inhibitor

A

Phenelzine
Selegiline (MAO B)
Trancylopromine

79
Q

medical management for serotonin syndrome

A

Cyproheptadine

80
Q

TRIAD of Opioid Overdose

A

pupillary constriction
Comatose
respiratory depression

81
Q

Maintenance therapy for Opioid dependence

82
Q

Meperidine + MAOi =

A

Hyperpyrexic Coma

83
Q

Meperidine + SSRI =

A

Serotonin syndrome

84
Q

this is 75-125x more POTENT than morphine

85
Q

Blood alcohol concentration that cause respiratory depression and death

A

> 500mg/dl

86
Q

Blood alcohol concentration that cause impaired motor function, slurred speech, ataxia

A

100-200mg/dl

Pharmacology (10 decks)

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