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CNS drugs Flashcards

1
Q

Antidote for Benzodiazepine

A

Flumazenil

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2
Q

site of action of Sedative-Hypnotic

A

GABA A receptor

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3
Q

Date Rape Drug

A

Flunitrazepam

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4
Q

most catastrophic symptom of sedative-hypnotic withdrawal

A

rebound suicide

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5
Q

this increases the DURATION of Cl ion channel opening

A

Barbiturates

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6
Q

his increases the FREQUENCY of Cl ion channel opening

A

Benzodiazipine

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7
Q

DOC for seizure in infant

A

Phenobarbital

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8
Q

antidote in methanol and ethylene glycol poisoning

A

Ethanol

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9
Q

DOC for Delireium Tremens

A

Long-acting Benzodiazipine – Diazepam, Chlordiazepoxide

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10
Q

DOC for Opioid overdose

A

Naloxone

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11
Q

DOC for opioid dependence and chronic alcoholism

A

Naltrexone

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12
Q

Sign and symptoms of Delirium Tremens 48-72 hrs post discontinuation

A

Hallucination
Autonomic instability
Delirium

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13
Q

DOC for absence seizure

A

Ethosuximide, Valproic acid

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14
Q

DOC for Myoclonic and Atypical Absence syndrome

A

Valproic acid

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15
Q

Management for Status Epilepticus

A

Phenytoin
Phenobarbital
Diazepam
Lorazepam

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16
Q

DOC for generalized tonic-clonic seziure

A

Valproic Acid
Phenytoin
Carbamazipine

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17
Q

DOC for partial seizure

A

Carbamazepine
Lamotrigine
Phenytoin

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18
Q

DOC for Trigeminal Neuralgia

A

Carbamazepine

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19
Q

Inhibitor of Alcohol dehydrogenase

A

Fomepizole

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20
Q

DOC for Opioid overdose

A

Naloxone

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21
Q

DOC for Opioid dependence and chronic alcoholism

A

Naltrexone

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22
Q

brain change seen in wenicke-korsakoff syndrome

A

hemorrhagic necrosis of the mamillary bodies

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23
Q

MC neurologic abnormality in chronic alcoholics

A

peripheral neuropathy

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24
Q

anti-seizure drug with greatest number of MOA

A

Topiramate - Na, Ca, K, GABA, AMPA-glutamate, carbonic anhydrase

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25
ALL Inhaled anes are bronchodilators, except:
Desflurane C/I in asthma
26
ALL Inhaled anes are vasodilator except
Isoflurane
27
Inhaled aned with highest potency
methoxyflurane lowest MAC
28
Has highest MAC but with lowest potency
Nitric oxide
29
Inhaled anes with Punget odor
Desflurane Enflurane
30
Inhaled anes with Sweet smelling odor
Sevoflurane Halothane
31
Halothane + Succinlycholine will cause __________
Malignant Hyperthermia
32
Induction agent of choice for unstable patient
Etomidate
33
Local anes with topical use
Benzocaine Tetracaine
34
antidote for LAST
Intralipid
35
All LA are vasodilator except
Cocaine
36
LA with shortest half life
Procaine
37
LA with longest half-life
Ropivacaine
38
S/E of Prilocaine is methomoglobinemia. what is the antidote
Methylene blue
39
Among NMB, Vecurinium has reversal dote
Sugammadex
40
Reversal of S/E of Nondepolarizing blockers
Neostigmine
41
Drugs used in Lethal injection
Pancuronium 100mg Potassium Cl 100meq Thiopental 5g
42
Non depolarizing blocker, that is DOC for hemodyanamic compromised
Cisatracurium Vecuronium Rocuronium
43
Drugs that undergo Hoffman Elimination that yields Laudanosine
Atracurium Cistracurium
44
Treatment for Malignant Hyperthermia
Dantrolene
45
IV anes with Adrenocortical suppression
Etomide
46
a ca channel blocker - blocks RyR1 Ca2 release channels in SR
Dantrolene
47
Dopamine precursor
Levedopa
48
Dopamine Agonits, Ergot
Bromocriptine - partial agonist at dopamine D2 receptor
49
D2 agonism leads to the inhibition of what hormone
inhibition of Prolactin release
50
Agonist at Dopamine D2 receptor
Opioid - Apomorphine
51
Side effect of MAO inhibitor
Serotonin syndrome
52
Cause Orange urine
COMT inhibitor: Tolcapone, -CAPONE
53
Anti viral drug used for parkinson
Amantidine
54
Side effect in using Antiviral drug for parkinson
Livedo reticularis
55
MAO inhibitors
Selegeline, Rasagiline
56
DOC for BIPOLAR disorder
Lithium
57
Schizo involves in excess activity of dopaminergic neuron in what pathway
mesolimbic-mesocortical pathway
58
Positive symptoms in Schizo:
HIDES hallucination illusion delusion excitement suspiciousness
59
It blocks more D2 receptor > 5HT2a receptor
Typical/Classical antipsychotic: Phenothiazines, Chlorpromazine Thioridazine, Haloperidol
60
Blocks 5HT2A receptor > D2 receptor
Atypical Antipsychotic: Clozapine, Olanzapine, Risperidone, Aripiprazole
61
Typical Antipsychotic with MOST Mucarinic blockade
Thiorodazine
62
has the highest potential for EPS
Haloperidol
63
DOC for refractory and suicidal schizo
Clozapine
64
Only approves anti-psychotic in schizo in the YOUTH
Risperidone, Paliperidone
65
TCA toxicity
Coma Cardiotoxicity Convulsions
66
DOC for major depressive Disorder
Fluoxetine
67
it inhibits neural reuptake of serotonin by inhibiting Serotonin Transporter
SSRI Fluoxetine, Paroxetine, Citalopram, Escitalopram
68
Lethal dose of TCA overdose
15mg/kg
69
Toxic dose of TCA overdose
7mg/kg
70
Medical management of TCA overdose
Bicarbonate
71
SSRI that is only approved for OCD
Fluvoxamine
72
Side effect of TCA
anticholinergic effects Histamine block effect alpha blocking effects
73
SNRI
Venlafaxine Duloxetine
74
drugs can cause Priapism
Trazadone Papaverine Sildenafil Quetiapine Alprostadil Warfarin Bupropion
75
Tricyclic Antidepressant
Imipramine Clomipramine Desipramine
76
Tetra Antidepressant
Amoxapine Maprotiline
77
Increases amine release from nerve ending by antagonism of presynaptic a2 adrenoceptors; Blocks serotonin 5HT2 receptor
Mirtazapine
78
MAO inhibitor
Phenelzine Selegiline (MAO B) Trancylopromine
79
medical management for serotonin syndrome
Cyproheptadine
80
TRIAD of Opioid Overdose
pupillary constriction Comatose respiratory depression
81
Maintenance therapy for Opioid dependence
Methadone
82
Meperidine + MAOi =
Hyperpyrexic Coma
83
Meperidine + SSRI =
Serotonin syndrome
84
this is 75-125x more POTENT than morphine
Fentanyl
85
Blood alcohol concentration that cause respiratory depression and death
>500mg/dl
86
Blood alcohol concentration that cause impaired motor function, slurred speech, ataxia
100-200mg/dl

Pharmacology (10 decks)

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