Chemotherapy

Question 1

Drug causes Pulmonary Fibrosis

Answer 1

Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
MTX

Question 2

Rescue therapy for MTX

Answer 2

Leucuvorin

Question 3

Rescue therapy for Cyclophosphamide

Answer 3

MESNA

Question 4

Rescue therapy for Doxorubicin

Answer 4

Dexrazoxane

Question 5

Rescue therapy for Cisplatin

Answer 5

Amifostine

Question 6

Most specific for the S phase of the cell cycle

Answer 6

Cytarabine

Question 7

Use for Acute Leukemia (AML, ALL), CML in BLAST CRISIS

Answer 7

Cytarabine

Question 8

Antimetabolites mimics ___________-

Answer 8

purine and pyrimidine

Question 9

Prevent microtubule assembly –> arrest at M phase

Answer 9

Vincrisitine

Question 10

alkylating agent that is designed for brain tumors – highly lipophilic and can cross BBB

Answer 10

Nitrosureas

Question 11

Inhibits topoisomerase I

Answer 11

Topotecan

Question 12

Inhibits DNA topoisomerase II (DNA gyrase)

Answer 12

Etoposide

Question 13

Interferes with mitotic spindle

Answer 13

Paclitaxel

Question 14

inhibits de novo purine nucleotide synthesis

Answer 14

6-mercaptopurine

Question 15

causes THYMINELESS death of cells

Answer 15

5-fluorouracil

Question 16

Most specific for G2 PHASE

Answer 16

Bleomycin

Question 17

Reduces estrogen synthesis by inhibiting aromatase

Answer 17

Anastrozole

Question 18

Inhibits tyrosine kinase activity of the protein product of BCR ABL oncogene in CML

Answer 18

Imatinib

Question 19

inhibits binding of VEGF to VEGFR; inhibits tumor vascular permeability

Answer 19

Bevacizumab

Question 20

CD20 inhibitor

Answer 20

Rituximab

Question 21

Binds to EGFR and inhibits downstream EGFR signaling

Answer 21

cetuximab

Question 22

uses for Acute promyleocytic leukemia

Answer 22

all trans retinoic acid