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Pharmacology > Coagulation Disorders Drugs > Flashcards

Coagulation Disorders Drugs Flashcards

1
Q

MOA of Aspirin

A

Nonselective COX1 and COX2 inhibitor –> reduces production of TXA2

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2
Q

Potent platelet aggregation

A

Thrombaxane A2

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3
Q

Aspirin/Salicylate is associated with what blood disorder?
a. Hemophilia
b. Reye’s Syndrome
c. Von Willebrand
d. Polycythemia Vera

A

B. Reye’s Syndrome

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4
Q

Phosphodiesters inhibitors: Dipyridamole and Cilostazol. Which among the MOA is not true?
a. inhibit platelet activation
b. increase Calcium
c. increase cAMP
d. inhibits cAMP to AMP

A

B. reduces Calcium influx

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5
Q

The drugs that inhibit platelet aggregation by interfering with GPIIb/IIIa receptor binding to fibrinogen

A

Abciximab - Eptifibatide - Tirofiban

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6
Q

Cilostazol is C/I in px with:
a. DM
b. HF
c. CKD
d. PAD

A

B. HF - increases HR and rhythm

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7
Q

MOA of Clopidogrel?

A

inhibits the binding of ADP (P2Y12) to platelet receptor

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8
Q

This drug directly activates antithrombin?
a. Enoxaparin
b. Argatroban
c. Heparin
d. Vit. K

A

C. Heparin
Enoxaparin –> binds and potentiates effect of antithrombin III on factor Xa

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9
Q

Antidote to Heparin?

A

Protamine Sulfate

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10
Q

Anticoagulant responsible for Heparin induced Thrombocytopenia (HIT)?

A

Lepirudin - Desirudin - Bivaluridin - Argatroban - Dabigatran

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11
Q

Antidote to Thrombolytics?

A

Aminocaproic Acid/ Tranexamic Acid

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12
Q

Vitamin K dependent clotting factors?

A

II, VII, IX, X

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13
Q

Drug that is a Tissue plasminogen activator analog, that can be given in px with MI, ischemic stoke, Pulmonary embolism?
a. Tranexamic acid
b. Retiplase
c. Warfarin
d. Prasugrel

A

B. Retiplase

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14
Q

Warfarin inhibits?
a. ADP to platelet receptor
b. phosphodiesterase
c. tPA
d. Vit. K epoxide reductase

A

D. Vit. K epoxide reductase
this enzyme converts Reduced Vit K to Oxidized Vit K which is responsible for activation of II, VII, IX, X clotting factors

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15
Q

Mainly Contraindicated in DIC?
a. Antiplasmin
b. Antiplatelet
c. Anticoagulant
d. Fibrinolytics

A

A. Antiplasmin (TXA and Aminocaprioc Acid)
These inhibits fibrinolysis by inihbiting plasminogen –> exerting antiplasmin activity
They can cause thrombotic complications (MI, renal artery thrombosis)

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16
Q

HIT – IgG binds to Heparin + ____ complexes that activates platelet that causes Hypercoagulable state
a. Fibrinogen
b. Prothrombin
c. Stuart-Prower factor
d. Calcium Ions

A

d. Calcium Ions - PF4

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17
Q

Enumerate the Clotting Factors

A

I - Fibrogen
II - Prothrombin
III - Tissue Thromboplastin
IV - Calcium Ions
V - Labile Factor
VII - Stable Factor
VIII - Antihemophilic Factors
IX - Christmas Factor/ Plasma Thromboplastin Component
X - Stuart Prower Factor
XI - Plasma Thromboplastin Antecedent
XII - Hageman Factor

18
Q

Antidote to Warfarin toxicity?

A

Vitamin K

19
Q

Involved in Step 1 of hemostatis

A

local myogenic spasm a
Endothelin 1

20
Q

Involved in Adhesion in primary hemostasi

A

vWF and Gp1b

21
Q

Involved in Aggregation in primary hemostasis

A

Fibrinogen and Gp2b-3a

22
Q

involved in secondary hemostasis

A

PiTT
Extrinsic pathway - factor III
Intrinsic pathway - factor XII
Fibrin

23
Q

Involved in the resolution of the Hemostasis

A

Fibrinolysis/Plasmin

24
Q

irreversibly inhibits binding of ADP to platelet receptors –> reducing platelet aggregation

A

Clopidogrel, Ticlopidine, Prasugrel, TicaGrelor

25
Q

lethal dose for Aspirin toxicity

A

500mg/kg

26
Q

toxic dose for Aspirin toxicity

A

150mg/kg

27
Q

DOC for anticoagulation during pregnancy

A

Heparin - Indirect thrombin inhibitors

28
Q

binds and potentiates effect of antithrombin III on factor Xa

A

Enoxaparin, Fondaparinux, -PARIN

29
Q

management for HIT

A

LMW: Fondaparinux
Direct Thrombin inhibitor: Lepirudin

30
Q

Direct thrombin inhibitors

A

Lepirudin, Bivalirudin, Dabigatran, Argatroban

31
Q

monoclonal antibody used for reversal of Dabigatran toxicity

A

Idarucizumab

32
Q

Antidote for Fibrinolytics

A

Aminocaproic acid

33
Q

it inhibits tPA –> inhbits plasminogen activation

A

Tranexamic acid

34
Q

Uses for Hemophilia A, Von willebrand disease

A

ADH agonist - Desmopressin, Vasopressin

35
Q

ADP inhibitor

A

Clopidogrel, Prasugrel, Triclopidine

36
Q

GpIIB/IIIA inhibitor

A

Abciximab, Eptifibatide, Tirofiban

37
Q

Acid disorder of Aspirin toxicity

A

Repiratory alkalosis with HAGMA

38
Q

drug with highest oral Iron prepation

A

Fe carbonate/Carbonyl Iron

39
Q

medical management for acute Iron intoxication

A

Deferoxamine

40
Q

Management for Chronic Iron Intoxication

A

Defarasirox
Deferipone

41
Q

TRIAD of Hemochromatosis

A

Cirrhosis
DM
skin pigmentation

Pharmacology (10 decks)

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