Endocrine

Question 1

Dopamine agonist – it inhibits prolactin release

Answer 1

Bromocriptine, Pergolide (-GOLIDE)
cat B

Question 2

management for SIADH

Answer 2

Tolvaptan, Conivaptan

Question 3

type of DI with deficient secretion of ADH

Answer 3

Central DI
problem: brain itself

Question 4

this is associated with end-organ resistance to the effects of ADH

Answer 4

Nephrogenic DI
problem: Kidney

Question 5

Intermittent dose of GNRH agonist will cause

Answer 5

Stimulatory effect –> Inc FSH and LH

Question 6

Continuous dosage of GNRH agonist will cause

Answer 6

Inhibitory effect –> dec FSH and LH

Question 7

GNRH analogue must be administered with _______ in order to INHIBIT the effect of the stimulatory in continuous dosaging

Answer 7

Flutamide

Question 8

Mainstay of the treatment of postpartum hyperthyroidism esp in lactation

Answer 8

Methimazole

Question 9

DOC for Pregnant Hyperthyroidism in 1st trimester

Answer 9

PTU

Question 10

Cancer associated with RAI I131

Answer 10

Papillary Thyroid Ca

Question 11

it reduces size and vascularity of thyroid gland prior to surgery

Answer 11

Lugol Solution/ Potassium Iodide Saturated Solution

Question 12

Ingestion of Iodine will result to Hyperthyroidism

Answer 12

Jod Basedow Effect

Question 13

Ingestion of Iodine will result to Hypothyroidism

Answer 13

Wolff Chaikoff effect

Question 14

maximum effect seen after _______wks of therapy of hypothyroidism

Answer 14

6-8 weeks

Question 15

drugs can cause Drug-induced hyperthyroidism

Answer 15

CAM
Clofibrate
Amiodarone
Methadone

Question 16

Drugs inhibit peripheral conversion of T4 to T3

Answer 16

PTU
Propanolol
Hydrocortisone

Question 17

Glucocorticoid with HIGHEST anti-inflammatory potency

Answer 17

Dexamethasone/Betamethasone

Question 18

Mineralocorticoid with highest SALT-RETAINING POTENCY

Answer 18

Fludrocortisone

Question 19

Behavioral changes secondary to steroid used is termed

Answer 19

Steroid Rage

Question 20

DOC for pregnant patient with Cushing syndrome

Answer 20

Metyrapone - inhibits steroid 11-hydroxylation

Question 21

It causes a Clear cell vaginal adenocarcinoma in daughters of the mother taking this

Answer 21

Diethylstilbestrol

Question 22

Recommended OCP in breastfeeding mother for it does not affect lactation

Answer 22

Progestin only (Medroxy-Progesterone Acetate)

Question 23

For hormone receptor positive metastatic breast Ca resistance to Tamoxifen

Answer 23

Fluvestrant - Full estrogen receptor antagonist

Question 24

most potent form of testosterone

Answer 24

Dihydrotestosterone – essential in the devt of male secondary sexual characteristics

Question 25

All insulin preparation contains this mineral

Answer 25

Zinc

Question 26

Worse S/E of metformin

Answer 26

Lactic acidosis

Question 27

It increases target tissue sensitivity to insulin by activating the PPAR-gamma receptor

Answer 27

Thiazolidinedione - Pioglitazone, -GLITAZONE

Question 28

it inhibits intestinal a-glucosidases

Answer 28

Acarbose, Miglitol, Voglibose

Question 29

activates amylin receptors

Answer 29

Pramlintide - also used for DMT1

Question 30

OHA drug that has possible Thyroid Carcinoma risk

Answer 30

Liraglutide

Question 31

activates GLP 1 receptors

Answer 31

Exenatide, Liraglutide

Question 32

It inhibits DPP4 (degrades GLP1 and other incretins)

Answer 32

Sitagliptin, Saxagliptin , Lingaliptin

Question 33

Enzyme that converts Testosterone to Estrogen (Estradiol)

Answer 33

Aromatase

Question 34

most appropriate oral contraceptive for a patient with moderate acne?

Answer 34

Ethinyl estradiol/norgestimate - has less androgenic activity

Question 35

OHA drugs causes weight Loss

Answer 35

MSG Metformin SGLT2 inhibitor GLP1 receptor agonist

Question 36

OHA drugs causes weight Gain

Answer 36

Sulfonylureas Insulin TZD