Gene Linkage Flashcards

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1
Q

What is gene linkage

A

The tendency of DNA sequences that are close together on a chromosome to be inherited together

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2
Q

Who tested the flies for gene linkage

A

T H Morgan

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3
Q

What did THMorgan test on gene linkage

A

Flies

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4
Q

What are the two types of mutations

A

Chromosomal and gene

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5
Q

What is chromosomal mutation

A

Change in the number or structure of chromosomes

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6
Q

What is gene mutation

A

Permanent alteration in DNA sequence

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7
Q

What has change in the number or structure of chromosomes

A

Chromosomal mutation

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8
Q

What has permanent alteration to DNA sequence

A

Gene mutation

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9
Q

What are the five kinds of Chromosomal mutations

A
Deletion 
Duplication
Inversion
Translocation 
Nondisjunction
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10
Q

What are the types of gene mutation

A

Point

Frame shift

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11
Q

Duplication

A

Cystic fibrosis

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12
Q

Inversion

A

Hemophilia a

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13
Q

Deletion

A

Some cancers, CMT

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14
Q

Translocation

A

Translocation Down’s syndrome

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15
Q

Nondisjunction

A

Down syndrome

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16
Q

Cystic fibrosis

A

Duplication

17
Q

Hemophilia a

A

Inversion

18
Q

Some cancers, CMT

A

Deletion

19
Q

Translocation Down’s syndrome

A

Translocation

20
Q

Down’s syndrome

A

Nondisjunction

21
Q

Def of polyploidy

A

One too many chromosomes

22
Q

One too many chromosomes

A

Polyploidy

23
Q

Def of points mutation

A

Change in a single or a few neucleotide

24
Q

Change in a single or a few neucleotide

A

Point mutation

25
Q

Frameshift mutation

A

Number of nucleotides in a DNA sequence that is not divisible by three

26
Q

Number of nucleotides in a DNA sequence that is not divisible by three

A

Frameshift mutation

27
Q

Hypertrophic cardiomyopathy

A

Increase of muscle and heart disease