Gastrointestinal Lecture 6 Part 1 Functional Anatomy of the Liver Flashcards

1
Q

What do we know about the liver already?

A
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2
Q

Functional anatomy of the liver

A
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3
Q

Functional anatomy of the liver: circulation

A
  • The absorptive segments of the gastrointestinal tract drain into the hepatic portal vein
  • The liver receives arterial blood supply from the aorta, and venous drainage via the vena cava
  • The liver also receives blood supply from the hepatic portal vein, which drains from the stomach and intestines = “hepatic portal system”
  • Substances absorbed in the intestine (nutrients, toxins, drugs) must pass through the liver and be processed before entering the general circulation
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4
Q

Functional anatomy of the liver: hepatic lobules

A
  • Structure has central veins
  • Portal triad
  • chords of hepatocytes
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5
Q

Parts of the portal triad

A
  • branch of bile duct
  • branch of hepatic portal vein
  • branch of hepatic artery
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6
Q

How does the portal triad of the liver work?

A
  • Arterial blood flows from hepatic artery to central vein oxygenating hepatocytes*
  • Blood from the portal vein percolates between hepatocytes, emptying into the central vein*
  • Bile produced by hepatocytes drains into the bile duct*
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7
Q

What happens to Arterial and portal vein blood

A

percolates towards the central vein in hepatic sinusoids

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8
Q

How does blood interact with hepatocytes

A

Blood travelling through the hepatic sinusoids can flow through gaps in the endothelial cell layer (fenestrations), entering the space of Disse and coming in direct contact with the hepatocytes.

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