Gastroenterology - Small Intestine Flashcards
What are the functions of the small intestine?
- digestion of food
- absorption of nutrients
- barrier to infection
What makes up the villi?
- enterocytes
- digestive enzymes, carrier proteins, and goblet cells
- crypt cells
- lamina propria
- mucosal immune system
What is the main energy requirement for enterocytes?
glutamine
What is HGE and AHDS?
- Hemorrhagic Gastroenteritis
- Acute Hemorrhagic Diarrhea Syndrome
Which animals are more predisposed to HGE and AHDS?
small breeds
What is the result of HGE and AHDS?
marked hemoconcentration and fluid shifts
- typically requires hospitalization
- hypovolemic shock seen before dehydration
What are the clinical signs of HGE and AHDS?
hematemesis and hematochezia
What are the possible etiologies of HGE and AHDS?
- viral
- hypersensitivity reaction
- infection by Clostridium perfringens
How is HGE and AHDS treated?
- IV fluids
- antibiotics
- gastroprotectants
- antiemetics
- nutrition
What is the prognosis for HGE and AHDS?
- good with aggressive supportive care
- poor with severe hypoproteinemia or signs of sepsis
What tapeworms can infect the small intestine?
- Dipylidium caninum
- Taenia
- Echinococcus
How does an animal get infected with Dipylidium caninum?
ingestion of fleas
What is the typical sign associated with Dipylidium caninum infection?
peri-rectal irritation
What is the treatment for Dipylidium caninum?
Praziquantel
Fenbendazole
How is Toxocara canis/cati transmitted?
ingestion of eggs or maternal transmission
What are the clinical signs associated with Toxocara?
- vomiting of live worms
- unthriftiness
- diarrhea
What is the treatment for toxicara?
Fenbendazole
Pyrantel Pamoate
What are the clinical signs associated with protozoa infections?
diarrhea +/- weight loss
What is the pathology of a protozoa infection?
destruction of enterocytes and villi
How is Giardia diagnosed?
- direct smear
- cysts on fecal float
- IFA
- ELISA
How is Tritrichomonas foetus diagnosed?
- direct smear
- culture
- fecal PCR
What is the treatment for Giardia?
Fenbendazole +/- Metronidazole
How is Coccidia transmitted?
fecal-oral or predation
What are the clinical signs of a coccidia infection?
- weight loss, dehydration, +/- hemorrhage
- adults can be self-limiting
- young/immunocompromised: anorexia, vomiting, dehydration
How is Coccidia diagnosed?
- direct smear
- fecal float
How is Coccidia treated?
Sulfadimethoxine and supportive care
How is Cryptosporidium transmitted?
- fecal-oral
- contaminated food/water
What are the clinical signs of a Cryptosporidium infection?
- self-limiting small bowel diarrhea
- can extend into large intestine and other organs
How is Cryptosporidium diagnosed?
- direct smear and fecal float
- ELISA
- PCR
- Biopsy
How is Cryptosporidium treated?
Paromomycin
Tylosin
How is Toxoplasma gondii transmitted?
predation and fecal contamination
What are the clinical signs of toxoplasma infection?
- pneumonitis
- GIT signs
- encephalitis
- lymphadenopathy
- liver disease, pancreatitis
- chorioretinitis
- fever, weight loss, lethargy
How is Toxoplasma gondii diagnosed?
- fecal float (limited use)
- antibody titers (IgG, IgM)
How is Toxoplasma gondii treated?
- Clindamycin
- Trimethoprim-sulfonamide
- Supportive care
What is Pythium Insidiosum and how is it transmitted?
- aquatic fungus
- exposure to free standing water > penetration of skin or mucosa by zoospores