Gastroenterology - Large Intestine Flashcards
Describe the structure of the large intestine
- lacks large villi
- invaginations of surface epithelium form intestinal crypts
- “Crypts of Leiberkuhn”
(goblet cells, endocrine cells, epithelial cells)
What are the functions of the large intestine?
- convert digested food waste into feces
- mucus and bicarbonate secretion
- resorb water, Na, and Cl
What are the typical clinical signs associated with colonic disease?
- diarrhea or constipation
- frank blood, mucus
- tenesmus, dyschezia
- urgency
- no weight loss or vomiting
What is “stress” colitis, and how is it treated?
- acute large bowel diarrhea
- often self-limiting
- tx: diet change, probiotic, fiber, Metro if severe
What is Trichuris vulpus?
What does it cause?
How is it transmitted?
- whipworm
- causes acute or chronic large bowel diarrhea
- fecal-oral contamination (egg ingestion)
What are the clinical signs of a Trichuris vulpus infection?
- can be asymptomatic
- hematochezia
- mucoid diarrhea
- tenesmus
How is Trichuris vulpus diagnosed?
- fecal float (eggs)
- ELISA
- colonoscopy in adults
How is Trichuris vulpus treated?
- Fenbendazole
- Preventatives
What is Heterobilharzia americana?
What does it cause?
- trematode/fluke
- “Schistosmiasis”
- acute or chronic large intestinal diarrhea
How is Heterobilharzia americana transmitted?
- reservoirs (small mammals)
- intermediate host (snails)
What is Tritrichomonas foetus?
What does it cause?
- protozoa that lives in descending colon and cecum
- chronic large intestinal diarrhea
What are the clinical signs of a Tritrichomonas foetus infection?
- large intestinal diarrhea
- tenesmus, fecal incontinence
- painful edematous rectum
How is Tritrichomonas foetus diagnosed?
- direct fecal smear
- PCR most sensitive
- fecal pouch culture
How is Tritrichomonas foetus treated?
- may be self-limiting
- Ronidazole
What is Prototheca?
- toxic algae found in soil and sewage
- blue-green algae bloom
What are the clinical signs of Prototheca infection?
Signs in dogs vs. cats?
- vomiting, diarrhea, ataxia, rapid death
- cats: cutaneous disease
- dogs: CNS, ocular, and large bowel signs
How is Prototheca diagnosed?
- culture
- rectal scraping
- biopsy
How is Prototheca treated?
Amphotericin B + Itraconazole
What is the prognosis for Prototheca infection?
- grave for disseminated dz
- guarded for cutaneous dz