Gas Transport Flashcards
How can we calculate the oxygen in our alveoli?
[Oxygen in our lungs] - [Oxygen used in our tissue]
How can we get oxygen (blood) to the tissue?
- Dissolved O2
- Hemoglobin
Why does oxygen not dissolve well in plasma?
Because it is lipophillic,
What is the solubility of O2 in the plasma?
0.3 ml O2/dl blood/ 100 mmHg
If the PaO2 is 100mmHg, how much oxygen will each dL of blood carry?
0.3 mL of O2
What is the metabolic demand of our heart?
250 mL of oxygen/ minute
How many times would our hearts have to pump to meet the metabolic demands of our heart of we could only transport oxygen by dissolving it in the blood?
83 liters of blood/ minute
What is PaO2?
The partial pressure of oxygen that is DISSOLVED in the arterial blood.
What is a better way to transport O2 in the blood?
Hb
How can we check how much oxygen is bound to Hb?
We can measure the dissolved O2 in our plasma, because it is in equillibrium with the amount bound to Hb.
What does the oxygen-Hb dissociation curve show?
It shows how oxygen is released from Hb.
It shows cooperativity- once one O2 binds to Hb, it makes it easier for others to bind.
PO2 in the systemic arteries is what?
What is the Hb saturation?
100.
This makes Hb about 100% saturated.
PO2 in the systemic veins is what?
What is the Hb saturation?
40.
At PO2 of 40, our Hb is 75 saturated.
How can we find the amount of oxygen that is unloaded to the tissue?
The percent difference from the arteries and veins is the % difference that is unloaded to the tissues.
When the PO2 is 60mmHg, what is the saturation?
85% saturation
At any PO2>60 mmHg, the Hb is at least ____ saturated with oxygen.
What does this mean?
85%.
At 100%, our oxygen content is 20.1 mL O2/dl of blood.
20.1 ml/dl blood * 85%=
At 85%, we have 17mL of O2/ dl blood.
What does a leftward shift in the Hb-O2 curve for HbA show?
An increase in affinity of Hb for O2.
O2 loads onto Hb easier, making less O2 available to be used by the tissue (because it wants to stay bound?
What does a right shift in the Hb-O2 curve of HbA show?
What does this mean?
Rightward shift–> the affinity for Hb for O2 is decreased.
Therefore, it is not holding onto the O2 as tightly and wants to deliver it to the tissue.
Metabollically active tissue wants a _______ affinity for oxygen.
Shift to the _____.
Decrease
RIGHT
What factors affect the affinity of Hb for O2?
- CO2 and/or pH
* *We cannot change CO2 without changing the pH.* - Temperature
- 2,3 DPG
When CO2 and or pH changes the Hb-O2 curve, what is this called?
Bohr effect.
How does CO2, pH or H+ affect the curve?
- High CO2= High H+ = low pH= shift to the right= decrease in the affinity
- Low CO2= low H+= high pH= left shit= increase affinity
How does temperature affect the Hb-O2 curve?
Increase temperature= right shift= decrease affinity
Decreased temperature= left shift= increase affinity
How does 2,3 DPG affect the Hb-O2 curve?
Increase 2,3 DPG= right shift= decrease affinity
Low 2,3 DPG= left shift = increase affinity