Gallbladder Disease Flashcards
What are the 2 common types?
Cholelithiasis
Cholecystitis
What is Cholelithiasis
Most common disorder of biliary system
Stones in the gallbladder
What is Cholecystitis
- Inflammation of the gallbladder
- Usually associated with cholelithiasis
What causes Cholelithiasis
- Cause of gallstones unknown
- Develops when balance that keeps cholesterol, bile salts, and calcium in solution is altered, leading to precipitation
- Bile secreted by liver supersaturated with cholesterol (lithogenic)
- Stasis of bile → supersaturation and changes in composition of bile (biliary sludge)
- Immobility, pregnancy, and inflammatory or obstructive lesions of biliary system ↓ bile flow
Causes of pain
- Stones may remain in gallbladder or may migrate to cystic or common bile duct
- Cause pain as they pass through ducts
- May lodge in ducts and produce an obstructio•Stones may remain in gallbladder or may migrate to cystic or common bile duct
- Cause pain as they pass through ducts
- May lodge in ducts and produce an obstructionn
What causes Cholecystitis
•Most commonly associated with obstruction from stones or sludge
•Acalculous cholecystitis: Inflammation without stones. Could be critically ill pts, TPN, DM, Ecoli
- Older adults and critically ill
- Prolonged immobility, fasting, parenteral nutrition, diabetes
- Bacteria or chemical irritants
- Adhesions, neoplasms, anesthesia, opioids
Cholecystitis where is the inflammation Inflammation
- Confined to mucous lining or entire wall
- Gallbladder is edematous and hyperemic-increased blood supply
- May be distended with bile or pus
- Cystic duct may become occluded
- Scarring and fibrosis after attack
Clinical manifestations
- Vary from severe to none at all
- Pain more severe when stones moving or obstructing
- Steady, excruciating
- Tachycardia, diaphoresis, prostration: extremely weak
- May be referred to shoulder/scapula
- Residual tenderness in RUQ
- Occur 3–6 hours after high-fat meal or when patient lies down
- Inflammation
- Leukocytosis
- Fever
- Physical examination findings
- RUQ tenderness (Murphy’s sign)
- Abdominal rigidity
Cinical manifestations of Chronic cholecystitis
- Fat intolerance
- Light-colored stools- no bile due to liver obstructed
- Dyspepsia
- Heartburn
- Flatulence
Symptoms of total obstruction
Jaundice: Lack of bile in blood
Dark amber urine-increased water soluble bilirubin
Clay-colored stools
Pruritus- itching due to bile salts in our skin tissue
Intolerance of fatty foods
Bleeding tendencies: Issues with absorption of Vitamin K= decreased production of prothrombin
Steatorrhea- Oily and foul odor in stool
Diagnostic Studies
- Ultrasonography
- Endoscopic Retrograde Cholangio-pancreatography (ERCP): Involves cystic and liver fatty duct and common bile duct. Allows us to look at those structures and do biopsies
- Percutaneous transhepatic cholangiography- insertion of needle int•Ultrasonography
- Endoscopic Retrograde Cholangio-pancreatography (ERCP): Involves cystic and liver fatty duct and common bile duct. Allows us to look at those structures and do biopsies
- Percutaneous transhepatic cholangiography- insertion of needle into gallbladder injects dye into ito gallbladder injects dye into it
Laboratory Tests
↑ WBC count
↑ Serum bilirubin level
↑ Urinary bilirubin level
↑ Liver enzyme levels
↑ Serum amylase level: Pancrease is involved. Secondary pancreatitis
Treatment
- Treatment dependent on stage of disease
- Oral dissolution therapy
- Ursodeozycholic acid (ursodiol [Actigall])
- Chenodeozycholic acid (chenodiol)
- ERCP with sphincterotomy
- Visualization
- Dilation
- Placement of stents
- Open the sphincter of Oddi, if needed
- Endoscope passed to duodenum
- Stones removed with basket or allowed to pass in stool
Collaborative Care
- Pain control
- NSAIDs
- Anticholinergics
- Control infection
- Antibiotic treatment
- Cholecystectostomy
- Maintenance of F&E balance
- NG tube if severe nausea/vomiting
Surgical Therapy
Laparoscopic cholecystectomy
Treatment of choice
Removal of gallbladder through one to four puncture holes
Minimal postoperative pain
Resume normal activities, including work, within 1 week
Few complications