Fungicides Flashcards

1
Q

what is pentachlorophenol??????

A

fungicide

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2
Q

most toxic route of exposure of PCP?

A

dermal!! especially for newborns

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3
Q

if you got dared to lick the wood in a barn than was treated with PCP can you get toxicosis???

A

yes dont do it!!!

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4
Q

do these factors increase or decrease PCP toxicosis?? high temp, oily solves vehicle, previous exposure, poor condition, newborn, hyperthyroidism

A

INCREASE

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5
Q

do these factors increase or decrease PCP toxicosis? cold temp, antithyroid drugs, presence of fat

A

DECREASE

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6
Q

3 places PCP is absorbed in body?

A

GIT, inhalation, skin

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7
Q

where does PCP accumulate in body?

A

well distributed throughout but stored in FAT

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8
Q

what is PCP conjugated to?

A

glucuronic acid

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9
Q

how is PCP excreted?

A

as glucuronides or unchanged in urine

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10
Q

how long after exposure will residues in tissues and fat be depleted from body?

A

one week

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11
Q

T/F: PCP MOA is that it binds up hemoglobin in blood and causes increased O2 demand

A

NOOOoOOOO! it uncouples oxidative phosphorylation and blocks/decreases ATP so O2 demand is increased in an effort to produce more ATP! O2 demand is more than supply (bad!!!!)

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12
Q

PCP toxicosis decreases O2 demand?

A

FALSE INCREASES IT

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13
Q

4 places PCP irritates on body?

A

eye, resp tract, GI mucosa, skin

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14
Q

signs of acute PCP toxicosis?

A

can be so fast no signs seen!!! hyperthermia, tachycardia, dyspnea, cyanosis, seizure, collapse, death

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15
Q

signs of chronic PCP toxicosis?

A

weight loss, decreased milk production, anemia, fetal malformations and abortions

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16
Q

a sheep died (sad) and the farmer is confused because he noticed “it got al stiff a lot faster than the other dead critters ive seen”! aka rapid rigor mortis. What toxicity is known to cause this?

A

PCP!

17
Q

What causes the dark blood seen in PCP toxicosis?

A

O2 deprivation

18
Q

chronic PCP toxicosis causes _______ of skin and ___________ of the urinary bladder mucosa???/

A

hyperkeratosis, villous like hyperplasia

19
Q

best specimens for PCP lab analysis in an alive animal and dead animal???

A

Alive: blood and urine
Dead: kidney and skin

20
Q

Tx of PCP?????

A

no antidote :( detoxify w/ emetics or gastric lavage of 5% sodium bicarb, charcoal or mineral oil), supportive and symptomatic therapy