Fungicides Flashcards
what is pentachlorophenol??????
fungicide
most toxic route of exposure of PCP?
dermal!! especially for newborns
if you got dared to lick the wood in a barn than was treated with PCP can you get toxicosis???
yes dont do it!!!
do these factors increase or decrease PCP toxicosis?? high temp, oily solves vehicle, previous exposure, poor condition, newborn, hyperthyroidism
INCREASE
do these factors increase or decrease PCP toxicosis? cold temp, antithyroid drugs, presence of fat
DECREASE
3 places PCP is absorbed in body?
GIT, inhalation, skin
where does PCP accumulate in body?
well distributed throughout but stored in FAT
what is PCP conjugated to?
glucuronic acid
how is PCP excreted?
as glucuronides or unchanged in urine
how long after exposure will residues in tissues and fat be depleted from body?
one week
T/F: PCP MOA is that it binds up hemoglobin in blood and causes increased O2 demand
NOOOoOOOO! it uncouples oxidative phosphorylation and blocks/decreases ATP so O2 demand is increased in an effort to produce more ATP! O2 demand is more than supply (bad!!!!)
PCP toxicosis decreases O2 demand?
FALSE INCREASES IT
4 places PCP irritates on body?
eye, resp tract, GI mucosa, skin
signs of acute PCP toxicosis?
can be so fast no signs seen!!! hyperthermia, tachycardia, dyspnea, cyanosis, seizure, collapse, death
signs of chronic PCP toxicosis?
weight loss, decreased milk production, anemia, fetal malformations and abortions
a sheep died (sad) and the farmer is confused because he noticed “it got al stiff a lot faster than the other dead critters ive seen”! aka rapid rigor mortis. What toxicity is known to cause this?
PCP!
What causes the dark blood seen in PCP toxicosis?
O2 deprivation
chronic PCP toxicosis causes _______ of skin and ___________ of the urinary bladder mucosa???/
hyperkeratosis, villous like hyperplasia
best specimens for PCP lab analysis in an alive animal and dead animal???
Alive: blood and urine
Dead: kidney and skin
Tx of PCP?????
no antidote :( detoxify w/ emetics or gastric lavage of 5% sodium bicarb, charcoal or mineral oil), supportive and symptomatic therapy
