Detergents, Phenols, Bleaches

Question 1

order cationic, anionic and non-ionic detergents in order of most to least toxic

Answer 1

cationic > anionic > non-ionic

Question 2

MOA of detergents?

Answer 2

direct irritation to skin and MM, cationic quaternary ammonium compounds can be corrosive –> systemic neurotoxicity

Question 3

MOA of phenols?

Answer 3

direct denature + precipitation of proteins –> coagulative necrosis, hepatotoxic, nephrotoxic, neurotoxic

Question 4

2 things bleach toxicity is dependent on?

Answer 4

hypochlorite ion and pH

Question 5

MOA of bleaches?

Answer 5

combined w/ acids or ammonia - hypochlorous acid + release of chlorine or chloramine gas = severe resp and eye irritation