From pharm, Prostaglandins and shit

Question 1

Prostacyclin PGI2 causes

Answer 1

inhibits platelet aggregation

vasodilation

Question 2

Thromboxane A2 TXA2 causes

Answer 2

platelet aggregation

vasoconstriction

Question 3

PGF2 causes

Answer 3

uterine contraction

Question 4

Zileuton is a

Answer 4

leukotriene synthesis inhibitor

5 lipoxygenase inhibitor

Question 5

Montelukast is a

Answer 5

CysLT1 receptor antagonist

Question 6

Prostacyclin PGI2 and Prostaglandin PGE2 work together to

Answer 6

preserve the integrity of the gastric lining

Question 7

which prostanoid activates inflammation and nociceptor sensitization

Answer 7

prostaglandin PGE2

Question 8

Tell me about Aspirin’s MOA big fella?

Answer 8

irreversibly binds to Cox-1 and inhibits enzyme for the life of the platelet
inhibition of thromboxane A2 synthesis =decreased platelet aggregation

Question 9

NSAIDS MOA?

Answer 9

inhibition of cox enzyme activity and reduction of synthesis of PGs (PGE2) (PGI2) etc.

Question 10

Samters triad

Answer 10

nasal polyps
asthma
aspirin intolerance