Fouty/Barrington: Immunosuppression

Question 1

Answer 1

Howell-Jolly bodies (individuals who have impaired splenic function or lack spleen)

Question 2

patients who lack a spleen or who’s spleen is dysfunctional are susceptible to infection by what organism

Answer 2

H. influenzae (encapsulated)

Question 3

important function of the spleen

Answer 3

filter blood (marginal zone)

Question 4

immune defense for person lacking a spleen

Answer 4

antibody mediated (B cells)

Question 5

________ organisms; asplenic patients at risk for these

Answer 5

encapsulated

Question 6

Answer 6

Haemophilus influenzae

Question 7

patient with chronic RA, and taking prednisone at an increased risk for infection with what organism

Answer 7

Nocardia asteroides

Question 8

Complex mediates and regulates transcription of a number of different genes; promote expression of genes that downregulate inflammation

Answer 8

MoA of corticosteroids

Question 9

Net effect of corticosteroids

Answer 9

suppress inflammation and inflammatory response

Question 10

immune defense for patients on corticosteroids

Answer 10

CD4 (Th1)—–macrophage activation by IFNgamma and TNFa

Question 11

patient’s steroid use puts them at increased risk for:

Answer 11

viruses
Nocardia (intracellular pathogens)

Question 12

branching filaments of what

Answer 12

Nocardia asteroides

Question 13

hx of RA, put on TNF receptor antagonist, now complains of night sweats, cough, weight loss

Answer 13

reactivation of TB

Question 14

Answer 14

cavitary lesion

Question 15

pt with RA on TNF receptor antagonist most susceptible to infection with what organism

Answer 15

Mycobacterium tuberculosis

Question 16

Th1 cells and activated ____ produce TNFa

Answer 16

macrophages

Question 17

one of the drugs of choice for RA

Answer 17

Etanercept (TNFa inhibitor)

Question 18

immune defense for patient with RA on TNFa receptor inhibitor, and also has reactivation of TB

Answer 18

CD4 (Th1) macrophage activation

Question 19

____ is important in maintaining granuloma formation

Answer 19

TNFa

Question 20

acid fast bacilli

Answer 20

M. tuberculosis

Question 21

man with HIV, CD4 count 693; not on anti-retroviral therapy increased risk for infection with what organism

Answer 21

Streptococcus pneumoniae

Question 22

____ infects CD4 T cells

Answer 22

HIV

Question 23

immune defense of patient with HIV and CD4 count of 693

Answer 23

CD4 T cells and CD8 T cells and production of antibody (Ab mediated and cell-mediated)

Question 24

____ response is important to fight off S. pneumoniae due to being encapsulated

Answer 24

IgG (antibody response)

Question 25

gram + diplococci

Answer 25

streptococcus pneumoniae

Question 26

patient with HIV and CD4 count of 145; not on any retrovirals susceptible to infection with what organism

Answer 26

Pneumocystis jiroveci

Question 27

Answer 27

Pneumocystis jiroveci

Question 28

patient with HIV and CD4 count of 25 susceptible to infection with what organism

Answer 28

CMV (Cytomegalovirus)

Question 29

immune defense in someone with HIV and low CD4 count

Answer 29

adaptive immunity

Question 30

Answer 30

CMV