Formation of major organs Flashcards
What three things derive from the ectoderm?
Surface ectoderm
Neural tube
Neural crest
What is the surface ectoderm?
Epidermis
Hair and nails
Olfactory and mouth epithelia
Lens and cornea
What is the neural tube?
Brain
Spinal cord
Motor neurons
Retina
What is the neural crest
PNS Adrenal medulla Melanocytes Facial cartilage Dentine
What is the first stage of neurulation?
Formation of medial hinge point in the neural plate
Notochord
Dorso-lateral hinge points meet and form neural crest
How many days until the neural tube has closed?
23 days after fertilisation
What disorders could arise from neural tube malfunction?
Anencephaly
Spina bifida
What is folate?
Vitamin B9
What is folate’s role?
Crucial in neural tube foundation
Recommended consumption of 400microg in first 12 weeks
What are the three derivatives of the mesoderm?
Paraxial mesoderm
Intermediate mesoderm
Lateral plate mesoderm
What is the paraxial mesoderm?
Axial skeleton
Axial muscles
Limb muscles
What is the intermediate mesoderm?
Urogenital system
What is the lateral plate mesoderm?
Limb skeleton
Mesentries
Blood, heart and circulatory system
What happens to the lateral plate mesoderm?
Separates into two layers
Somatic mesoderm
Sphlanchnic mesoderm
What is somitogenesis?
Formation of somites
What are somites?
Spheres of cells surrounding a central lumen
Either side of the neural tube
What shape is the embryo at 4 weeks after fertilisation?
Flat
Oval
Trilaminar
Disc
What happens to the shape of the embryo at 4 weeks?
The left and right edges of the embryonic disc move ventrally, constricting the neck of the yolk sack
What is the result of lateral folding?
Ectodermal, mesodermal and endodermal layers on both sides fuse
Ectoderm covers the entire surface of the embryo
Coelom forms
Splanchic mesoderm lines the visceral organs
Somatic mesoderm forms body wall
Gut forms
What is cephalocaudal folding?
At the same time as lateral folding occurs
Results in formation of foregut and hindgut
What two tubes does the endoderm give rise to?
Digestive tube
Respiratory tube
What does the anterior portion of the foregut develop into?
Pharynx
Thymus
Parathyroid glands
What does the remainder of the foregut form?
Liver
Gall bladder
Pancreas