Fischer Final Flashcards
General Procedure:
- add stirbar, …, 5.7 mL …, 5.4 mL …, and … (conc.) to a Rb. Fk
- reflux for 1 hr
- put receiving fk in …
- add … to separatory funnel
- add … to rxn flask; pipette into sep. funnel. extract 2x.
- add … to dry org. layer. transfer into rb. fk and add na2so4. store
- set up a … distill off pentane. switch receiving flask and collect … (have ice bath under receiving fk)
- determine RI, IR, and weight
molecular sieves; glacial acetic acid; 3-methyl-1-butanol; H2SO4; ice bath; diluted 2.5% NaHCO3; pentane; Na2SO4; semimicro distillation; ester
purpose of molecular sieves: …, pushes equilibrium towards product formation
absorbs h2o
anhydrous conditions are necessary initially to … towards product formation
push equilibrium
the NaHCO3 neutralizes the … and …
excess acetic acid; H2SO4
Na2SO4 is needed when storing in case the ester is exposed to H2O in air which would cause it to …
hydrolyze
ice bath is used in semimicro distillation to prevent
evaporation of ester
excess acetic acid is used to propel
the equilibrium towards product formation
what is the purpose of adding concentrated (and not dilute) sulfuric acid?
It’s not dilute bc the amount of … must be minimized to drive the equilibrium towards …
water; product formation
you can’t use base-catalysis bc base would ..
hydrolyze ester once its formed
at the beginning if you use base it would …, creating …, reducing electrophilicity of C
react w/ acetic acid; sodium acetate
acetic acid must be neutralized or ester will undergo
acid catalyzed hydrolysis
H2O formed comes from
carboxylic acid
(toxicity) 3-methylbutanol: skin …, serious …, acute toxicity, skin ..
corrosion; eye damage; sensitization
(toxicity) ethanoic acid: …, serious …
skin corrosion; eye damage
(toxicity) pentane: acute toxicity, … and … irritation, … sensitization; … sensitization
skin; eye; skin; respiratory
