Aspirin

Question 1

general procedure for aspirin:

1. …. salicylic acid and acetic anhydride into E. Fk
   2) Add …
   3) … E.Fk in a …
   4) Add .. mL … water down flask wall. Store
   5) …

Answer 1

weight out; H2SO4 dropwise; heat; hot water bath; 18; hot; vacuum filter

Question 2

sulfuric acid is used instead of HCl bc the chloride ion from HCl will …, producting an unwanted byproduct (acid chloride)

Answer 2

react w/ salicylic acid

Question 3

the direct, intense flame of a Bunsen burner is hot enough to … as it forms. by using a water bath, the rxn is heated more …, and max temp doesn’t exceed 100

Answer 3

decompose the aspirin; gently

Question 4

water is added to … the reaction, … the excess …, and cause crude aspirin to …

Answer 4

quench; destroy; acetic anhydride; crystallize

Question 5

in water, acetic anhydride slowly converts to …, and this, …, and water are infinitely miscible

Answer 5

acetic acid; H2SO4

Question 6

the salicylic acid and acetic anhydride was heated to increase … and collision of particles. synthesis of aspirin is an … rxn, and adding heat … the rxn to favor …

Answer 6

solubility; endothermic; pushes; product formation

Question 7

ethanoic anhydride is added in excess bc it acts as the … and also ensures the rxn would go to completion in case … is present

Answer 7

solvent; water

Question 8

(toxicity) salicylic acid: … of skin/eye; eye …; … and … throat

Answer 8

redness; pain; cough; sore

Question 9

(toxicity) ethanoic anhydride (acetic anhydride): …, … eyes; eye …/…; …, skin …, …, …; cough; .. of ..

Answer 9

watery, red; pain/burns; blisters; burns, pain, redness; shortness of breath

Question 10

(toxicity) sulfuric acid: irritated …, …, …, and …; eye, skin …; …, … of …

Answer 10

skin; eyes; nose; throat; burns; blisters; shortness of breath

Question 11

(toxicity) acetylsalicylic acid (aspirin): eye …, …; skin …

Answer 11

redness; pain; redness