Final Exam: Quizzes Flashcards
Hansen (2004): Ephrins and Retinal Axons:
Which Ephrin was the main focus?
Ephrin A
Hansen (2004): Ephrins and Retinal Axons:
Did temporal axons growth better on anterior or posterior membrane?
Anterior
Hansen (2004): Ephrins and Retinal Axons:
Axons from which part of the retina showed the most outgrowth in response to Ephrin-AS?
Nasal
Hansen (2004): Ephrins and Retinal Axons:
How did the researchers precluster the ephrin?
Antibodies
Buss (2006): neuromuscular Development/PCD
Name 2 animal models used.
1) Bax KO mouse
2) mayo GDNP mouse
3) Paralytic Chick
Buss (2006): neuromuscular Development/PCD
With what is motor size associated?
motor functioning/motor ability
Buss (2006): neuromuscular Development/PCD
What does the presence of abnormal bundled unmyelinated axons suggest?
Atrophy
Buss (2006): neuromuscular Development/PCD
Name one behavioral test used to test adult mice in this paper?
Balance beam
Buss (2006): neuromuscular Development/PCD
Where did the researchers get their eggs?
Tyson
Niell (2004): Synapse formation on growing dendritic arbor
The researchers used 2 fluorescent markers/proteins. What were they and what were they used to mark?
GFP (PSD-95)
DSRed-arbun
These were used to mark dendrite breaks and filopodia, and stuff that would appear in synapse.
PSD-95 marks puncta.
Niell (2004): Synapse formation on growing dendritic arbor
Do the numbers of stable puncta increase or decrease over time?
Increase
Niell (2004): Synapse formation on growing dendritic arbor
According to the results of the paper, how do filopodial puncta/synapses convert to shaft synapses and puncta
By gradually growing, interacting with environment/dendritic arbors, and eventually stabilizing. This is illustrated in figures which show the gradual steps of synapse function.
Niell (2004): Synapse formation on growing dendritic arbor
Do authors think:
1) formation of stable puncta –> filopodia stabilization
2) stabilization filopodia –> puncta stabilize
formation of stable puncta/synapses allow filopodia to stabilize
Winnubst (2015)- spontaneous activity and synaptic plasticity
What does asynchronous activity do to neighboring synapses?
Depresses/destabilizes their activity
Winnubst (2015)- spontaneous activity and synaptic plasticity
Did absolute activity level at synapses correlate with co-activity levels?
No, they found it was unaffected by Ca2+ amplitudes
Winnubst (2015)- spontaneous activity and synaptic plasticity
Which ligand-receptor pair did the authors suggest was responsible for the effects seen following desynchronized activity?
ProBDNF and p75NTR
Winnubst (2015)- spontaneous activity and synaptic plasticity
On which 2 parts of the brain did the authors focus?
Visual cortex
Hippocampus
Winnubst (2015)- spontaneous activity and synaptic plasticity
“Out of sync-….”
Lose your link
Zhong (2018)- Retinoic Acid and homeostatic Plasticity
The authors had 2 main questions they wanted to address in the study. State one of them.
How does RA affect synaptic strength/homeostatic plasticity IN VIVO?
Zhong (2018)- Retinoic Acid and homeostatic Plasticity
Does RA primarily affect excitatory or inhibitory synaptic transmission in L2/3 in the postcritical period?
Inhibitory
Zhong (2018)- Retinoic Acid and homeostatic Plasticity
To try to figure out which cell subtypes RA signaling acts upon, the research selectively deleted what from different cell populations?
RAR2
Zhong (2018)- Retinoic Acid and homeostatic Plasticity
Why did the researchers investigate the role of FMRP?
It is involved in fragile X
Zhong (2018)- Retinoic Acid and homeostatic Plasticity
How did the researchers causes visual deprivation?
Ablation
Ruthazer (2003)- Axon dynamics and correlated activity
What animal and part of the brain did they use in this paper?
Tadpole
Tectum
Ruthazer (2003)- Axon dynamics and correlated activity
How did the researchers cause dual innervation of this structure?
They ablated the tectum on one side
Ruthazer (2003)- Axon dynamics and correlated activity
Where were ipsilateral branches most likely to be lost?
In contralateral eye (opposite)
Elimination in contralateral
Ruthazer (2003)- Axon dynamics and correlated activity
Which receptors do the researchers suggest are required for correlation detection/activity dependent branch tip stabilization or elimination?
NMDA receptors
