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Developmental Neurobiology 🧠 > Final Exam: Quizzes > Flashcards

Final Exam: Quizzes Flashcards

1
Q

Hansen (2004): Ephrins and Retinal Axons:

Which Ephrin was the main focus?

A

Ephrin A

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2
Q

Hansen (2004): Ephrins and Retinal Axons:

Did temporal axons growth better on anterior or posterior membrane?

A

Anterior

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3
Q

Hansen (2004): Ephrins and Retinal Axons:

Axons from which part of the retina showed the most outgrowth in response to Ephrin-AS?

A

Nasal

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4
Q

Hansen (2004): Ephrins and Retinal Axons:

How did the researchers precluster the ephrin?

A

Antibodies

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5
Q

Buss (2006): neuromuscular Development/PCD

Name 2 animal models used.

A

1) Bax KO mouse
2) mayo GDNP mouse
3) Paralytic Chick

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6
Q

Buss (2006): neuromuscular Development/PCD

With what is motor size associated?

A

motor functioning/motor ability

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7
Q

Buss (2006): neuromuscular Development/PCD

What does the presence of abnormal bundled unmyelinated axons suggest?

A

Atrophy

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8
Q

Buss (2006): neuromuscular Development/PCD

Name one behavioral test used to test adult mice in this paper?

A

Balance beam

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9
Q

Buss (2006): neuromuscular Development/PCD

Where did the researchers get their eggs?

A

Tyson

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10
Q

Niell (2004): Synapse formation on growing dendritic arbor

The researchers used 2 fluorescent markers/proteins. What were they and what were they used to mark?

A

GFP (PSD-95)
DSRed-arbun

These were used to mark dendrite breaks and filopodia, and stuff that would appear in synapse.

PSD-95 marks puncta.

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11
Q

Niell (2004): Synapse formation on growing dendritic arbor

Do the numbers of stable puncta increase or decrease over time?

A

Increase

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12
Q

Niell (2004): Synapse formation on growing dendritic arbor

According to the results of the paper, how do filopodial puncta/synapses convert to shaft synapses and puncta

A

By gradually growing, interacting with environment/dendritic arbors, and eventually stabilizing. This is illustrated in figures which show the gradual steps of synapse function.

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13
Q

Niell (2004): Synapse formation on growing dendritic arbor

Do authors think:

1) formation of stable puncta –> filopodia stabilization
2) stabilization filopodia –> puncta stabilize

A

formation of stable puncta/synapses allow filopodia to stabilize

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14
Q

Winnubst (2015)- spontaneous activity and synaptic plasticity

What does asynchronous activity do to neighboring synapses?

A

Depresses/destabilizes their activity

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15
Q

Winnubst (2015)- spontaneous activity and synaptic plasticity

Did absolute activity level at synapses correlate with co-activity levels?

A

No, they found it was unaffected by Ca2+ amplitudes

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16
Q

Winnubst (2015)- spontaneous activity and synaptic plasticity

Which ligand-receptor pair did the authors suggest was responsible for the effects seen following desynchronized activity?

A

ProBDNF and p75NTR

17
Q

Winnubst (2015)- spontaneous activity and synaptic plasticity

On which 2 parts of the brain did the authors focus?

A

Visual cortex

Hippocampus

18
Q

Winnubst (2015)- spontaneous activity and synaptic plasticity

“Out of sync-….”

A

Lose your link

19
Q

Zhong (2018)- Retinoic Acid and homeostatic Plasticity

The authors had 2 main questions they wanted to address in the study. State one of them.

A

How does RA affect synaptic strength/homeostatic plasticity IN VIVO?

20
Q

Zhong (2018)- Retinoic Acid and homeostatic Plasticity

Does RA primarily affect excitatory or inhibitory synaptic transmission in L2/3 in the postcritical period?

A

Inhibitory

21
Q

Zhong (2018)- Retinoic Acid and homeostatic Plasticity

To try to figure out which cell subtypes RA signaling acts upon, the research selectively deleted what from different cell populations?

A

RAR2

22
Q

Zhong (2018)- Retinoic Acid and homeostatic Plasticity

Why did the researchers investigate the role of FMRP?

A

It is involved in fragile X

23
Q

Zhong (2018)- Retinoic Acid and homeostatic Plasticity

How did the researchers causes visual deprivation?

A

Ablation

24
Q

Ruthazer (2003)- Axon dynamics and correlated activity

What animal and part of the brain did they use in this paper?

A

Tadpole

Tectum

25
Q

Ruthazer (2003)- Axon dynamics and correlated activity

How did the researchers cause dual innervation of this structure?

A

They ablated the tectum on one side

26
Q

Ruthazer (2003)- Axon dynamics and correlated activity

Where were ipsilateral branches most likely to be lost?

A

In contralateral eye (opposite)

Elimination in contralateral

27
Q

Ruthazer (2003)- Axon dynamics and correlated activity

Which receptors do the researchers suggest are required for correlation detection/activity dependent branch tip stabilization or elimination?

A

NMDA receptors

Developmental Neurobiology 🧠 (11 decks)

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