Filoviridae & Bornaviridae

Question 1

Filoviridae
enveloped or non-enveloped
RNA or DNA
pathogens of _______

Answer 1

enveloped
-ssRNA
primates & hemorrhagic fevers

Question 2

Ebola Hemorrhagic Fever
host:
reservoir:
transmission:
disease:
clinical disease found in ____ but not _____
zoonotic?

Answer 2

host: primates, swine
reservoir: fruit bats
transmission: direct contact, fomites, aersoles?, human-human contact
disease: hemorrhagic fever
clinical dz in non-human primates, pigs, rodents but not dogs or fruit bats
zoonotic

Question 3

Ebola Hemorrhagic Fever
diagnostics:
passive immunity:
vx:

Answer 3

diagnostics: virus isolation, electron microscopy, ELISA, IF, PCR
passive immunity: inmazeb
vx: Ervebo, Zabdeno + Mvabea

Question 4

Bornaviridae
enveloped or non-enveloped
RNA or DNA

Answer 4

enveloped, spherical
-ssRNA

Question 5

Borna Disease Virus
host:
reservoir host:
disease:
pathogenesis:
treatment/control:
diagnostics:
zoonotic?
reportable?

Answer 5

host: wide host range, esp. horses
reservoir host: rodents
disease: encephalomyelitis, neuro deficits, paralysis
pathogenesis: CNS via olfactory n. and replicates in neurons, astrocytes, oligodendrocytes, “Joest-degen” bodies
treatment/control: no treatment or vx, quarantine
diagnostics: PCR
zoonotic
reportable

Question 6

differentials for borna disease virus

Answer 6

rabies, tetanus, EHV1, PEM, WNV, equine alphavirus encephalitides

Question 7

Avian Bornavirus - Proventricular Dilation Disease
host:
transmission:
shed:
disease:
prevention/control:
diagnostics:
high prevalence in _______

Answer 7

host: psittacines, geese, waterfowl
transmission: aerosols?
shed: feces, urates, nasal passage
disease: Macaw wasting disease - GI & neuro
prevention/control: no treatment or vx; just quarantine
diagnostics: signs, rads w/ barium, PCR, serology, biopsy
high prevalence in water fowl and captive parrots