Fields- formation of male reproductive system Flashcards
_____ develop in the yolk sac
germ cells
migrate to genital ridge (L1) where they develop into gametes (sperm)
germ cells
aggressive tumors; contains more than one cell type
non-seminomas
contains one cell type; highest cure rate at 95%
seminoma
3 major germ cell tumor markers
AFP, LDH, beta hCG
from intermediate mesoderm
gonads
intermediate mesoderm (genital ridge) to _____ gonad (genital ridge) at weeks 5-6
indifferent
responsible for testes formation; Y linked
SRY gene product (TDF: testis determining factor)
_______derived cells migrate into the intermediate mesoderm where the testes are forming
peritoneum
peritoneum derived cells form _____ around the germ cells
sex cords
derived from sex cords and is where sperm is being developed
seminiferous tubules
derived from sex cords and moves sperm to efferent ductules
Rete Testis
moves sperm to epididymis
efferent ductules
derived from peritoneum
rete testes
seminiferous tubule
sertoli cells
derived from fibroblast
Leydig cell
_____ tumors are the most common testicular tumors
germ cell tumors
Choriocarcinoma
Yolk Sac
Embryonal
Teratoma
types of germ cell tumors
germ cell tumor
Produces estrogen.
Produces Androgen Binding Protein;
binds and transports testosterone.
Produces Inhibin.
Mullerian Inhibiting Factor
Sertoli cell
produces testosterone
produces estradiol 17beta
Leydig cell
After age 40, testosterone levels decrease by 1% each year leading to ____
Andropause
2 ducts that form genital ridge
Mullerian and Wolffian
responsible for male sex organs
Wolffian duct
responsible for female sex organs
Mullerian duct
B.
duct that is mesonephric
Wolffian duct
duct that is paramesonephric
Mullerian duct
remnants of Mullerian(paramesonephric) duct in males
appendix testis
prostatic utricle
uterovaginal primordium
appendix testis
associated with:
Low Mullerine Inhibiting Factor (MIF) from sertoli cells
Resistance to MIF
enlarged prostatic utricle
responsible for formation of Wolffian duct
testosterone
mesonephric duct remnant
appendix epididymis
mesonephric duct remnant
paradidymal cyst
spermatocele
ectasia rete testis
epididymal cyst
testicular pain needs to be taken seriously due to the possibility of what
torsion
2 main mesonephric (Wolffian) duct remnants
epididymal appendix
paradidymis
main paramesonephric duct remnant (Mullerian)
testicular appendix
irritation and swelling of epididymis due to bacterial infection
epididymitis
Seminiferous tubules
Rete testes
derived from:
peritoneum
seminal vesicle
ejaculatory duct
epididymis
appendix epididymis
tubules
vas deferens
efferent ductules
derived from:
mesonephric duct
appendix testis
prostatic utricle
derived from:
paramesonephric duct
shortens and drags testes into scrotum so sperm can function better at lower temp.
Gubernaculum
descends in the normal path but does not reach scrotum
Cryptorchid testis
descends in the normal path to the superficial inguinal ring, then tracks to other sites within the superficial fascia
Ectopic testis
surgery for cryptorchid or ectopic testis
Orchiopexy
in normal descent of testes, proximal portion of ______ undergoes apoptosis
vaginal process
______ is on anterior aspect of testes
tunica vaginalis
If the proximal portion of the Vaginal process does not undergo apoptosis, a large patency of the vaginal process is continuous with the peritoneal cavity.
Intestines may herniate into the scrotum.
congenital inguinal hernia
A small patency of the vaginal process.
This results in a fluid filled cyst in the anterior scrotum.
hydrocele of testes
fluid in tunica vaginalis of testes
hydrocele
______ septum from mesoderm origin splits cloaca
urorectal septum
3 parts of external genitalia formation
genital tubercle
genital folds
genital swellings
elongates to form the shaft and glans penis
genital tubercle
comes together to enclose the open ventral surface of the spongy/penile urethra
genital folds; urethral fold
comes together to form
the scrotum
genital swellings/Labioscrotal swellings
___ and ___ form shaft
crus and bulb of penis
ventral side of penis
corpus spongiosum
dorsal side of penis
corpus cavernosum
failure of the genital folds to fuse ventrally
hypospadius
ventral bending
chordee
failure of the dorsal mesenchyme of the shaft (genital tubercle) to properly fuse
epispadius
testosterone into DHT by what
5alpha-reductase
4 main things that DHT helps form
penis
scrotum
prostate
bulbourethral glands
treatment for boys with anomalies of male genitalia
testosterone
treatment for male adults for anomalies of male genitalia
hCG
Androgen is responsible for development of external structures
XY- male
Infertile
Testosterone not getting into cells and being converted to DHT
to develop external genitalia
Androgen Insensitivity syndrome
Reifenstein Syndrome
Partial Androgen Insensitivity
46 XY; absence of sex chromatin in nuclei; varying degree of
development to internal and external genitalia; inadequate
production of testosterone and mullerian inhibiting factor
male pseudohermaphoditism
structures derived from ______ duct are sensitive to testosterone
Mesonephric (Wolffian)
structures derived from _____ and _____ sensitive to DHT
endoderm and mesoderm