fibrates Flashcards
1
Q
example
A
bezafibrate
2
Q
main indication
A
Hypertriglyceridemia - first line for patients with very high TAG levels
3
Q
mechanism of action
A
Act as agonists of a nuclear receptor to enhance the transcription of several genes, including those encoding LDL - enhances clearance
4
Q
contraindications and cautions
A
Best avoided in alcoholics - predisposed to hypertriglyceridaemias, but also rhabdomyolosis
5
Q
administration
A
PO
6
Q
adverse effects
A
have few adverse effects, like statins might cause myositis
